Match!

Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis

Published on Jul 1, 2005in Gut17.943
· DOI :10.1136/gut.2004.052316
Wolfgang Stremmel75
Estimated H-index: 75
,
Uta Merle22
Estimated H-index: 22
+ 3 AuthorsRobert Ehehalt31
Estimated H-index: 31
Sources
Abstract
Background and aims: We examined the hypothesis of an anti-inflammatory effect of phosphatidylcholine in ulcerative colitis. Methods: A phase IIA, double blind, randomised, placebo controlled study was performed in 60 patients with chronic active, non steroid dependent, ulcerative colitis, with a clinical activity index (CAI) of ⩾4. Retarded release phosphatidylcholine rich phospholipids and placebo were administered at a dose of 6 g daily over three months. The primary end point was a change in CAI towards clinical remission (CAI ⩽3) or CAI improvement by ⩾50%. Secondary end points included ⩾50% changes in endoscopic activity index (EAI), histology, and quality of life scores. Results: Induction of clinical remission (CAI ⩽3) as the primary outcome variable was attained by 16 (53%) patients in the phosphatidylcholine treated group compared with three (10%) in the placebo group (p Conclusion: Retarded release oral phosphatidylcholine is effective in alleviating inflammatory activity caused by ulcerative colitis.
Figures & Tables
  • References (24)
  • Citations (125)
📖 Papers frequently viewed together
68 Citations
88 Citations
90 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References24
Newest
#1Robert Ehehalt (Heidelberg University)H-Index: 31
#2Christina Jochims (Heidelberg University)H-Index: 1
Last. Wolfgang Stremmel (Heidelberg University)H-Index: 75
view all 7 authors...
Background: Intestinal mucus not only facilitates substrate absorption, but also forms a hydrophobic, phosphatidylcholine (PC) enriched, barrier against luminal gut contents. Methods: For evaluation of the origin of PC in intestinal mucus, we first analyzed the mucus PC in mice with absent biliary phospholipid secretion (mdr2 (−/−) mice) using electrospray ionization (ESI) tandem mass spectroscopy (MS/MS). Second, in situ perfused rat jejunum, ileum and colon were analyzed after i.v. bolus injec...
34 CitationsSource
#1Robert Ehehalt (University Hospital Heidelberg)H-Index: 31
#2J. Wagenblast (DKFZ: German Cancer Research Center)H-Index: 1
Last. Wolfgang Stremmel (University Hospital Heidelberg)H-Index: 75
view all 7 authors...
88 CitationsSource
#1Elsa Anes (University of Lisbon)H-Index: 20
#2Mark Kühnel (EMBL-EBI: European Bioinformatics Institute)H-Index: 4
Last. Gareth Griffiths (EMBL-EBI: European Bioinformatics Institute)H-Index: 76
view all 6 authors...
Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria
208 CitationsSource
#1Sean G. NugentH-Index: 3
#2Devinder KumarH-Index: 33
Last. Df EvansH-Index: 16
view all 4 authors...
Measurements of luminal pH in the normal gastrointestinal tract have shown a progressive increase in pH from the duodenum to the terminal ileum, a decrease in the caecum, and then a slow rise along the colon to the rectum. Some data in patients with ulcerative colitis suggest a substantial reduction below normal values in the right colon, while limited results in Crohn9s disease have been contradictory. Determinants of luminal pH in the colon include mucosal bicarbonate and lactate production, b...
324 CitationsSource
#1Heiko C. Rath (UNC: University of North Carolina at Chapel Hill)H-Index: 12
#2Michael Schultz (UNC: University of North Carolina at Chapel Hill)H-Index: 24
Last. Ryan B. SartorH-Index: 78
view all 8 authors...
Resident bacteria are incriminated in the pathogenesis of experimental colitis and inflammatory bowel diseases. We investigated the relative roles of various enteric bacteria populations in the induction and perpetuation of experimental colitis. HLA-B27 transgenic rats received antibiotics (ciprofloxacin, metronidazole, or vancomycin-imipenem) in drinking water or water alone in either prevention or treatment protocols. Mice were treated similarly with metronidazole or vancomycin-imipenem before...
292 CitationsSource
#1Claudia Veltkamp (UNC: University of North Carolina at Chapel Hill)H-Index: 4
#2Susan L. Tonkonogy (NCSU: North Carolina State University)H-Index: 22
Last. Ryan B. Sartor (UNC: University of North Carolina at Chapel Hill)H-Index: 78
view all 8 authors...
Abstract Background & Aims: Normal resident bacteria are required for development of colitis in several rodent models. We determined whether bacterial stimulation is necessary for both induction and perpetuation of mucosal inflammation and T-cell activation in Tgϵ26 mice, in which transplantation of wild-type bone marrow (BM⇒Tgϵ26) causes colitis under specific pathogen–free (SPF) conditions. Methods: BM from (C57BL/6 × CBA/J) F1 mice was transplanted into germfree (GF) or SPF Tgϵ26 mice. Mesent...
105 CitationsSource
Background: Oral and topical mesalazine formulations are effective in active ulcerative colitis, but little is known on the efficacy of combined treatment. Aim: To compare the efficacy of oral mesalazine vs. combined oral and topical mesalazine in mildly to moderately active ulcerative colitis. Methods: Patients with mildly to moderately active ulcerative colitis (Clinical Activity Index, CAI 4–12) were identified at 15 participating centres. They were randomized to receive either mesalazine 4 g...
60 CitationsSource
#1ClaudioFiocchi (Case Western Reserve University)H-Index: 65
The field of gastroenterology offers many challenges to both the clinician and the investigator, but few are as complex and enigmatic as inflammatory bowel disease (IBD). Crohn’s disease (CD) and ulcerative colitis (UC) have been known for well over one half a century, but why affected individuals spend their lives with a chronic inflammatory process that relentlessly destroys their bowel remains a mystery. Advances, although unequal in different areas, have been plentiful in the last decade whe...
1,788 CitationsSource
#1C. J. Foltz (MIT: Massachusetts Institute of Technology)H-Index: 5
#2James G. Fox (MIT: Massachusetts Institute of Technology)H-Index: 84
Last. David B. Schauer (MIT: Massachusetts Institute of Technology)H-Index: 38
view all 7 authors...
101 CitationsSource
#1John L. Wallace (U of C: University of Calgary)H-Index: 51
#2D. N. Granger (U of C: University of Calgary)H-Index: 38
The association between colonization of the stomach by Helicobacter pylori and peptic ulcer disease has stimulated a renewal of interest in the factors that render the gastric mucosa resistant to injury induced by endogenous secretions and ingested toxins. Mucosal defense consists of a complex network of components that function in concert with one another. This network includes: 1) the extramucosal components such as acid, mucus, surface-active phospholipids, and bicarbonate; 2) the epithelium ...
288 CitationsSource
Cited By125
Newest
#1Milica Markovic (BGU: Ben-Gurion University of the Negev)H-Index: 4
#2Shimon Ben-Shabat (BGU: Ben-Gurion University of the Negev)H-Index: 15
Last. Arik Dahan (BGU: Ben-Gurion University of the Negev)H-Index: 33
view all 5 authors...
The aim of this work is to analyze relevant endogenous lipid processing pathways, in the context of the impact that lipids have on drug absorption, their therapeutic use, and utilization in drug delivery. Lipids may serve as biomarkers of some diseases, but they can also provide endogenous therapeutic effects for certain pathological conditions. Current uses and possible clinical benefits of various lipids (fatty acids, steroids, triglycerides, and phospholipids) in cancer, infectious, inflammat...
Source
New research is leading us to a broader understanding of the role of the gastrointestinal tract. No longer is it thought to be merely a conduit for food and waste; it is recognized that the GI tract partakes of bidirectional relationships with the nervous system, the immune system, the endocrine system, and with overall metabolism. Many of these 2effects are mediated via the microbiome. GI disorders are exceptionally asmenable to natural interventions. The potential role of functional medicine i...
Source
#1Eduard F. StangeH-Index: 42
#2Bjoern O. Schroeder (Umeå University)H-Index: 11
Last. Bjoern O. Schroeder (Umeå University)H-Index: 1
view all 2 authors...
ABSTRACTIntroduction: Inflammatory bowel diseases (IBD) are on the rise worldwide. This review covers the current concepts of the etiology of Crohn´s disease and ulcerative colitis by focusing on a...
1 CitationsSource
#1Tim J. Wooster (Nestlé)H-Index: 20
#2Simone Acquistapace (Nestlé)H-Index: 8
Last. B.L. Dekkers (Nestlé)H-Index: 1
view all 5 authors...
Abstract The on demand delivery of novel peptide actives, traditional pharmaceuticals, nutrients and/or vitamins is a ever present challenge due to the digestive and metabolic degradation of the active and the delivery vehicle. Biodegradable biopolymer hydrogels have long held promise as candidates for creating tailored release profiles due to the ability to control gel porosity. The present study describes the creation of novel hierarchical biopolymer hydrogels for the controlled release of lip...
1 CitationsSource
#1Philipp SchreinerH-Index: 2
#2Markus F. NeurathH-Index: 99
Last. GerhardRoglerH-Index: 63
view all 9 authors...
Background: Although TNF inhibitors revolutionized the therapy of inflammatory bowel disease (IBD), we have been reaching a point where other therapies with different mechanisms of action are necessary. A rising number of elderly IBD patients with contraindications to established therapies and a growing group of patients losing response to anti-TNF therapy compel us to find safer, better-tolerated, and, ideally, personalized treatment options. However, in order to choose the right drug to fit a ...
Source
#1G. Brett Moreau (UVA: University of Virginia)H-Index: 2
#2Girija Ramakrishnan (UVA: University of Virginia)H-Index: 11
Last. William A. Petri (UVA: University of Virginia)H-Index: 64
view all 10 authors...
Abstract Background Undernutrition is a serious global problem that contributes to increased child morbidity and mortality, impaired neurocognitive development, and decreased educational and economic attainment. Current interventions are only marginally effective, and identification of associated metabolic pathways can offer new strategies for intervention. Methods Plasma samples were collected at 9 and 36 months from a subset of the PROVIDE child cohort (n = 130). Targeted metabolomics was perf...
Source
#1Carina L. Chittim (Harvard University)H-Index: 3
#2Ana Martínez-del Campo (Harvard University)H-Index: 3
Last. Emily P. Balskus (Harvard University)H-Index: 24
view all 3 authors...
The essential nutrient choline is metabolized by gut bacteria to the disease-associated metabolite trimethylamine (TMA). However, most of the choline obtained via the diet and present in the human body is incorporated into larger metabolites, including the lipid phosphatidylcholine (PC). Here, we report that many choline-utilizing gut microorganisms can hydrolyse PC using a phospholipase D (PLD) enzyme and further convert the released choline to TMA. Genetic and in vitro characterization of the ...
3 CitationsSource
1 CitationsSource
#1Anthony F. Juritsch (NU: University of Nebraska–Lincoln)H-Index: 1
#2Regis F Moreau (NU: University of Nebraska–Lincoln)H-Index: 6
2 CitationsSource
#1Funmilola A. Ayeni (UI: University of Ibadan)H-Index: 7
#2Elena Biagi (UNIBO: University of Bologna)H-Index: 29
Last. Silvia Turroni (UNIBO: University of Bologna)H-Index: 26
view all 13 authors...
Summary We assessed the subsistence-related variation of the human gut microbiome at a fine resolution for two of the main dimensions of microbiome variation, age and geography. For this, we investigated the fecal microbiome and metabolome in rural Bassa and urbanized individuals from Nigeria, including infants, and compared data with worldwide populations practicing varying subsistence. Our data highlight specific microbiome traits that are progressively lost with urbanization, such as the domi...
16 CitationsSource