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Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis

Published on Jul 1, 2005in Gut17.94
· DOI :10.1136/gut.2004.052316
Wolfgang Stremmel73
Estimated H-index: 73
,
Uta Merle22
Estimated H-index: 22
+ 3 AuthorsRobert Ehehalt25
Estimated H-index: 25
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Abstract
Background and aims: We examined the hypothesis of an anti-inflammatory effect of phosphatidylcholine in ulcerative colitis. Methods: A phase IIA, double blind, randomised, placebo controlled study was performed in 60 patients with chronic active, non steroid dependent, ulcerative colitis, with a clinical activity index (CAI) of ⩾4. Retarded release phosphatidylcholine rich phospholipids and placebo were administered at a dose of 6 g daily over three months. The primary end point was a change in CAI towards clinical remission (CAI ⩽3) or CAI improvement by ⩾50%. Secondary end points included ⩾50% changes in endoscopic activity index (EAI), histology, and quality of life scores. Results: Induction of clinical remission (CAI ⩽3) as the primary outcome variable was attained by 16 (53%) patients in the phosphatidylcholine treated group compared with three (10%) in the placebo group (p Conclusion: Retarded release oral phosphatidylcholine is effective in alleviating inflammatory activity caused by ulcerative colitis.
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  • References (22)
  • Citations (122)
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References22
Newest
Published on Jun 1, 2004in Biochimica et Biophysica Acta3.79
Robert Ehehalt25
Estimated H-index: 25
(Heidelberg University),
Christina Jochims1
Estimated H-index: 1
(Heidelberg University)
+ 4 AuthorsWolfgang Stremmel73
Estimated H-index: 73
(Heidelberg University)
Abstract Background : Intestinal mucus not only facilitates substrate absorption, but also forms a hydrophobic, phosphatidylcholine (PC) enriched, barrier against luminal gut contents. Methods : For evaluation of the origin of PC in intestinal mucus, we first analyzed the mucus PC in mice with absent biliary phospholipid secretion (mdr2 (−/−) mice) using electrospray ionization (ESI) tandem mass spectroscopy (MS/MS). Second, in situ perfused rat jejunum, ileum and colon were analyzed after i.v. ...
Published on Jan 1, 2004in Scandinavian Journal of Gastroenterology2.15
Robert Ehehalt13
Estimated H-index: 13
(University Hospital Heidelberg),
J. Wagenblast1
Estimated H-index: 1
(DKFZ: German Cancer Research Center)
+ 4 AuthorsWolfgang Stremmel73
Estimated H-index: 73
(University Hospital Heidelberg)
Background: A defective mucus composition represents a key pathogenetic factor for intestinal injury. Phosphatidylcholine (PC) is an essential component contributing to formation of a hydrophobic mucus layer. For evaluation of PC in the pathogenesis of inflammatory bowel disease, the concentration and composition of PC in the rectal mucus of patients with ulcerative colitis was determined. Electrospray ionization (ESI) tandem mass spectrometry (MS/MS) allows quantification of PC species and enab...
Published on Sep 1, 2003in Nature Cell Biology17.73
Elsa Anes18
Estimated H-index: 18
(University of Lisbon),
Mark Kühnel4
Estimated H-index: 4
(EMBL-EBI: European Bioinformatics Institute)
+ 3 AuthorsGareth Griffiths70
Estimated H-index: 70
(EMBL-EBI: European Bioinformatics Institute)
Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria
Published on Apr 1, 2001in Gut17.94
Sean G. Nugent2
Estimated H-index: 2
,
Devinder Kumar34
Estimated H-index: 34
+ 1 AuthorsDavid F. Evans16
Estimated H-index: 16
Measurements of luminal pH in the normal gastrointestinal tract have shown a progressive increase in pH from the duodenum to the terminal ileum, a decrease in the caecum, and then a slow rise along the colon to the rectum. Some data in patients with ulcerative colitis suggest a substantial reduction below normal values in the right colon, while limited results in Crohn9s disease have been contradictory. Determinants of luminal pH in the colon include mucosal bicarbonate and lactate production, b...
Published on Apr 1, 2001in Infection and Immunity3.16
Heiko C. Rath22
Estimated H-index: 22
(UNC: University of North Carolina at Chapel Hill),
Michael Schultz24
Estimated H-index: 24
(UNC: University of North Carolina at Chapel Hill)
+ 5 AuthorsRyan B. Sartor75
Estimated H-index: 75
Resident bacteria are incriminated in the pathogenesis of experimental colitis and inflammatory bowel diseases. We investigated the relative roles of various enteric bacteria populations in the induction and perpetuation of experimental colitis. HLA-B27 transgenic rats received antibiotics (ciprofloxacin, metronidazole, or vancomycin-imipenem) in drinking water or water alone in either prevention or treatment protocols. Mice were treated similarly with metronidazole or vancomycin-imipenem before...
Published on Mar 1, 2001in Gastroenterology19.23
Claudia Veltkamp4
Estimated H-index: 4
(UNC: University of North Carolina at Chapel Hill),
Susan L. Tonkonogy22
Estimated H-index: 22
(NCSU: North Carolina State University)
+ 5 AuthorsRyan B. Sartor75
Estimated H-index: 75
(UNC: University of North Carolina at Chapel Hill)
Abstract Background & Aims: Normal resident bacteria are required for development of colitis in several rodent models. We determined whether bacterial stimulation is necessary for both induction and perpetuation of mucosal inflammation and T-cell activation in Tgϵ26 mice, in which transplantation of wild-type bone marrow (BM⇒Tgϵ26) causes colitis under specific pathogen–free (SPF) conditions. Methods: BM from (C57BL/6 × CBA/J) F1 mice was transplanted into germfree (GF) or SPF Tgϵ26 mice. Mesent...
Published on Feb 5, 2001in Alimentary Pharmacology & Therapeutics7.73
Maurizio Vecchi44
Estimated H-index: 44
,
Gianmichele Meucci26
Estimated H-index: 26
+ 8 AuthorsGiovanni Fornaciari14
Estimated H-index: 14
Background: Oral and topical mesalazine formulations are effective in active ulcerative colitis, but little is known on the efficacy of combined treatment. Aim: To compare the efficacy of oral mesalazine vs. combined oral and topical mesalazine in mildly to moderately active ulcerative colitis. Methods: Patients with mildly to moderately active ulcerative colitis (Clinical Activity Index, CAI 4–12) were identified at 15 participating centres. They were randomized to receive either mesalazine 4 g...
Published on Jul 1, 1998in Gastroenterology19.23
ClaudioFiocchi62
Estimated H-index: 62
(Case Western Reserve University)
The field of gastroenterology offers many challenges to both the clinician and the investigator, but few are as complex and enigmatic as inflammatory bowel disease (IBD). Crohn’s disease (CD) and ulcerative colitis (UC) have been known for well over one half a century, but why affected individuals spend their lives with a chronic inflammatory process that relentlessly destroys their bowel remains a mystery. Advances, although unequal in different areas, have been plentiful in the last decade whe...
Published on Jun 1, 1998in Helicobacter3.35
Charmaine J. Foltz5
Estimated H-index: 5
(MIT: Massachusetts Institute of Technology),
James G. Fox88
Estimated H-index: 88
(MIT: Massachusetts Institute of Technology)
+ 4 AuthorsDavid B. Schauer38
Estimated H-index: 38
(MIT: Massachusetts Institute of Technology)
Published on May 1, 1996in The FASEB Journal5.39
John L. Wallace33
Estimated H-index: 33
(U of C: University of Calgary),
D. N. Granger60
Estimated H-index: 60
(U of C: University of Calgary)
The association between colonization of the stomach by Helicobacter pylori and peptic ulcer disease has stimulated a renewal of interest in the factors that render the gastric mucosa resistant to injury induced by endogenous secretions and ingested toxins. Mucosal defense consists of a complex network of components that function in concert with one another. This network includes: 1) the extramucosal components such as acid, mucus, surface-active phospholipids, and bicarbonate; 2) the epithelium ...
Cited By122
Newest
Published on Oct 1, 2019in Journal of Colloid and Interface Science6.36
Tim J. Wooster18
Estimated H-index: 18
(Nestlé),
Simone Acquistapace8
Estimated H-index: 8
(Nestlé)
+ 2 AuthorsB. L. Dekkers1
Estimated H-index: 1
(Nestlé)
Abstract The on demand delivery of novel peptide actives, traditional pharmaceuticals, nutrients and/or vitamins is a ever present challenge due to the digestive and metabolic degradation of the active and the delivery vehicle. Biodegradable biopolymer hydrogels have long held promise as candidates for creating tailored release profiles due to the ability to control gel porosity. The present study describes the creation of novel hierarchical biopolymer hydrogels for the controlled release of lip...
Published on May 1, 2019in EBioMedicine
G. Brett Moreau2
Estimated H-index: 2
(UVA: University of Virginia),
G. Brett Moreau + 7 AuthorsRashidul Haque38
Estimated H-index: 38
Abstract Background Undernutrition is a serious global problem that contributes to increased child morbidity and mortality, impaired neurocognitive development, and decreased educational and economic attainment. Current interventions are only marginally effective, and identification of associated metabolic pathways can offer new strategies for intervention. Methods Plasma samples were collected at 9 and 36 months from a subset of the PROVIDE child cohort ( n = 130). Targeted metabolomics was per...
Published on Jan 1, 2019in Nature microbiology14.30
Carina L. Chittim1
Estimated H-index: 1
(Harvard University),
Ana Martínez-del Campo3
Estimated H-index: 3
(Harvard University),
Emily P. Balskus22
Estimated H-index: 22
(Harvard University)
The essential nutrient choline is metabolized by gut bacteria to the disease-associated metabolite trimethylamine (TMA). However, most of the choline obtained via the diet and present in the human body is incorporated into larger metabolites, including the lipid phosphatidylcholine (PC). Here, we report that many choline-utilizing gut microorganisms can hydrolyse PC using a phospholipase D (PLD) enzyme and further convert the released choline to TMA. Genetic and in vitro characterization of the ...
Published on Dec 21, 2018in World Journal of Gastroenterology3.41
Elisabetta Antonelli26
Estimated H-index: 26
,
Vincenzo Villanacci39
Estimated H-index: 39
,
Gabrio Bassotti48
Estimated H-index: 48
Published on Aug 1, 2018in Nutrition Reviews5.78
Anthony F. Juritsch (NU: University of Nebraska–Lincoln), Régis Moreau5
Estimated H-index: 5
(NU: University of Nebraska–Lincoln)
Published on Jun 1, 2018in Cell Reports7.82
Funmilola A. Ayeni6
Estimated H-index: 6
(UI: University of Ibadan),
Elena Biagi27
Estimated H-index: 27
(UNIBO: University of Bologna)
+ 10 AuthorsStephanie L. Schnorr9
Estimated H-index: 9
(Konrad Lorenz Institute for Evolution and Cognition Research)
Summary We assessed the subsistence-related variation of the human gut microbiome at a fine resolution for two of the main dimensions of microbiome variation, age and geography. For this, we investigated the fecal microbiome and metabolome in rural Bassa and urbanized individuals from Nigeria, including infants, and compared data with worldwide populations practicing varying subsistence. Our data highlight specific microbiome traits that are progressively lost with urbanization, such as the domi...
Published on May 21, 2018in Nutrients4.17
Shilpa Tiwari-Heckler1
Estimated H-index: 1
,
Hongying Gan-Schreier6
Estimated H-index: 6
+ 2 AuthorsAnita Pathil14
Estimated H-index: 14
Background: Non-alcoholic fatty liver disease (NAFLD) is associated with inefficient macro- and micronutrient metabolism, and alteration of circulating phospholipid compositions defines the signature of NAFLD. This current study aimed to assess the pattern of serum phospholipids in the spectrum of NAFLD, and its related comorbidities and genetic modifications. Methods: 97 patients with diagnosed NAFLD were recruited at a single center during 2013–2016. Based on histological and transient elastog...
Published on May 1, 2018in Journal of Biomedical Materials Research Part A3.22
Martin Asama1
Estimated H-index: 1
,
Alex Hall1
Estimated H-index: 1
+ 5 AuthorsQun Wang1
Estimated H-index: 1
Published on Jan 1, 2018
Alyssa M. Parian6
Estimated H-index: 6
,
Gerard E. Mullin25
Estimated H-index: 25
+ 1 AuthorsAmy C. Brown13
Estimated H-index: 13
Published on Oct 1, 2017in Therapeutic Advances in Gastroenterology
Marcel Vetter3
Estimated H-index: 3
(FAU: University of Erlangen-Nuremberg),
Markus F. Neurath96
Estimated H-index: 96
(FAU: University of Erlangen-Nuremberg)
To improve quality of life and prevent long-term risks in patients with inflammatory bowel diseases (IBDs: Crohn’s disease, ulcerative colitis), it is essential to suppress inflammatory activity adequately. However, corticosteroids are only suitable for therapy of acute flares and the evidence for positive effects of immunosuppressive substances like azathioprine or 6-mercapropurine is mainly limited to maintenance of remission. In addition, only subgroups of patients benefit from biologicals ta...
View next paperPhosphatidylcholine for Steroid-Refractory Chronic Ulcerative Colitis: A Randomized Trial