Hypolipidaemic effects and mechanisms of the main component of Opuntia dillenii Haw. polysaccharides in high-fat emulsion-induced hyperlipidaemic rats

Published on Sep 1, 2012in Food Chemistry5.40
· DOI :10.1016/j.foodchem.2012.03.001
Long-Yan Zhao1
Estimated H-index: 1
(HAU: Hunan Agricultural University),
Wei Huang1
Estimated H-index: 1
(HAU: Hunan Agricultural University)
+ 4 AuthorsFuhua Zeng5
Estimated H-index: 5
(ZNU: Zhanjiang Normal University)
Abstract The antihyperlipidaemic effects of ODP-Ia, one of the main components of Opuntia dillenii Haw. polysaccharides, were studied. Gavage administration of ODP-Ia was observed to significantly decrease serum lipid levels and to increase serum high-density lipoprotein cholesterol level in hyperlipidaemic rats. Similar suppressive patterns were also seen in hepatic total cholesterol and triglyceride levels. Moreover, the ODP-Ia administration significantly increased serum lecithin:cholesterol acyltransferase activity, increased the production of serum NO, inhibited hepatic HMG-CoA reductase activity, augmented serum and hepatic superoxide dismutase activities and decreased the serum and hepatic malondialdehyde contents in hyperlipidaemic rats. In addition, a histopathological examination revealed that ODP-Ia administration significantly suppressed inflammatory cell infiltration and the expression of VCAM-1. Together, these results indicate that ODP-Ia is a potential natural product for the treatment of hyperlipidaemia-related diseases by improving antioxidant levels, modulating the activities of enzymes involved in cholesterol metabolism, promoting the production of NO and suppressing the expression of VCAM-1, thereby suppressing lipid accumulation and inflammatory cell infiltration.
  • References (34)
  • Citations (41)
#1Longyan Zhao (HAU: Hunan Agricultural University)H-Index: 6
#2Q.J. Lan (HAU: Hunan Agricultural University)H-Index: 1
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#1Giovanni MussoH-Index: 4
#2Roberto Gambino (UNITO: University of Turin)H-Index: 43
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#1Chia-Yen Dai (KMU: Kaohsiung Medical University)H-Index: 37
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#1Tomonori Sugiura (Nagoya City University)H-Index: 14
#2Yasuaki Dohi (Nagoya City University)H-Index: 28
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Cited By41
#1Hongliang Zeng (Fujian Agriculture and Forestry University)H-Index: 11
#2Peilin Chen (Fujian Agriculture and Forestry University)H-Index: 1
Last.Yi Zhang (Fujian Agriculture and Forestry University)H-Index: 13
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#1Lichun Chen (ZJSU: Zhejiang Gongshang University)
#2Bo-Kai Jiang (Zhejiang University of Science and Technology)
Last.Zhong-yang Fan (Zhejiang University of Science and Technology)
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#1Wenshuai Wang (SDAU: Shandong Agricultural University)H-Index: 3
#2Xinling Song (SDAU: Shandong Agricultural University)H-Index: 5
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#1Zi-Cheng Zhang (HAU: Huazhong Agricultural University)H-Index: 3
#2Qing Zhou (HUST: Huazhong University of Science and Technology)H-Index: 6
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