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Hypolipidaemic effects and mechanisms of the main component of Opuntia dillenii Haw. polysaccharides in high-fat emulsion-induced hyperlipidaemic rats

Published on Sep 1, 2012in Food Chemistry5.399
· DOI :10.1016/j.foodchem.2012.03.001
Long-Yan Zhao1
Estimated H-index: 1
(HAU: Hunan Agricultural University),
Wei Huang1
Estimated H-index: 1
(HAU: Hunan Agricultural University)
+ 4 AuthorsFuhua Zeng5
Estimated H-index: 5
(ZNU: Zhanjiang Normal University)
Sources
Abstract
Abstract The antihyperlipidaemic effects of ODP-Ia, one of the main components of Opuntia dillenii Haw. polysaccharides, were studied. Gavage administration of ODP-Ia was observed to significantly decrease serum lipid levels and to increase serum high-density lipoprotein cholesterol level in hyperlipidaemic rats. Similar suppressive patterns were also seen in hepatic total cholesterol and triglyceride levels. Moreover, the ODP-Ia administration significantly increased serum lecithin:cholesterol acyltransferase activity, increased the production of serum NO, inhibited hepatic HMG-CoA reductase activity, augmented serum and hepatic superoxide dismutase activities and decreased the serum and hepatic malondialdehyde contents in hyperlipidaemic rats. In addition, a histopathological examination revealed that ODP-Ia administration significantly suppressed inflammatory cell infiltration and the expression of VCAM-1. Together, these results indicate that ODP-Ia is a potential natural product for the treatment of hyperlipidaemia-related diseases by improving antioxidant levels, modulating the activities of enzymes involved in cholesterol metabolism, promoting the production of NO and suppressing the expression of VCAM-1, thereby suppressing lipid accumulation and inflammatory cell infiltration.
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#1Lauren N. Bell (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 12
#2Jean P. MollestonH-Index: 28
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#1Krzysztof Lukasz Kopec (Lahey Hospital & Medical Center)H-Index: 1
#2David L. Burns (Lahey Hospital & Medical Center)H-Index: 11
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Abstract The aim of this study was to determine the most effective hypoglycemic component of polysaccharides from Opuntia dillenii Haw. by preliminary screening and to specifically study the antidiabetic effects of O. dillenii polysaccharide (ODP)-Ia in mice with streptozotocin (STZ)-induced diabetes. Three kinds of ODPs – ODP-Ia, ODP-Ib, and ODP-II′ – were isolated by using an ultrasonic extraction method and diethylaminoethyl (DEAE)-Sepharose fast-flow column chromatography. The mice were admi...
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