The new frontier of genome engineering with CRISPR-Cas9
Abstract
The advent of facile genome engineering using the bacterial RNA-guided CRISPR-Cas9 system in animals and plants is transforming biology. We review the history of CRISPR (clustered regularly interspaced palindromic repeat) biology from its initial discovery through the elucidation of the CRISPR-Cas9 enzyme mechanism, which has set the stage for remarkable developments using this technology to modify, regulate, or mark genomic loci in a wide...
Paper Details
Title
The new frontier of genome engineering with CRISPR-Cas9
Published Date
Nov 28, 2014
Journal
Volume
346
Issue
6213
Pages
1258096 - 1258096
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Notes
History