ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use

Rebeca Acín-Pérez; Isabel Carrascoso; Francesc Baixauli; Marta Roche-Molina; Ana Latorre-Pellicer; Patricio Fernández-Silva; María Mittelbrunn; Francisco Sánchez-Madrid; Acisclo Pérez-Martos; Clifford A. Lowell; José Antonio Enríquez

doi:https://doi.org/10.1016/j.cmet.2014.04.015

doi.org/10.1016/j.cmet.2014.04.015

ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use

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..., José Antonio Enríquez

60

Cell Metabolism29.00

Volume: 19, Issue: 6, Pages: 1020 - 1033

Published: Jun 1, 2014

Abstract

Electron flux in the mitochondrial electron transport chain is determined by the superassembly of mitochondrial respiratory complexes. Different superassemblies are dedicated to receive electrons derived from NADH or FADH2, allowing cells to adapt to the particular NADH/FADH2 ratio generated from available fuel sources. When several fuels are available, cells adapt to the fuel best suited to their type or functional status (e.g., quiescent...

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Paper Details

Title

ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use

DOI

doi.org/10.1016/j.cmet.2014.04.015

Published Date

Jun 1, 2014

Journal

Cell Metabolism

Volume

19

Issue

6

Pages

1020 - 1033

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