Significance of quantitative measurement of heparin-induced platelet antibodies

Heparin-induced thrombocytopenia (HIT) is a prothrombotic immune-mediated adverse drug reaction. Antigen and platelet activation assays are used for detection of antibodies. Quantitative results from platelet factor 4 (PF4)-dependent immunoassays may lead to inter-laboratory standardization of measurements.The aim was to modify a PF4-dependent immunoassay to measure PF4/heparin antibodies quantitatively.Over five consecutive years, 1070 samples...