Molecular Signatures of Major Depression
Abstract
Adversity, particularly in early life, can cause illness. Clues to the responsible mechanisms may lie with the discovery of molecular signatures of stress, some of which include alterations to an individual's somatic genome. Here, using genome sequences from 11,670 women, we observed a highly significant association between a stress-related disease, major depression, and the amount of mtDNA (p = 9.00 × 10(-42), odds ratio 1.33 [95% confidence...
Paper Details
Title
Molecular Signatures of Major Depression
Published Date
May 1, 2015
Journal
Volume
25
Issue
9
Pages
1146 - 1156
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Notes
History