Glucose Stimulation of Hypothalamic MCH Neurons Involves KATP Channels, is Modulated by UCP2, and Regulates Peripheral Glucose Homeostasis

Volume: 12, Issue: 5, Pages: 545 - 552
Published: Nov 3, 2010
Abstract
Summary null Blood glucose levels are tightly controlled, a process thought to be orchestrated primarily by peripheral mechanisms (insulin secretion by β cells, and insulin action on muscle, fat, and liver). The brain also plays an important, albeit less well-defined role. Subsets of neurons in the brain are excited by glucose; in many cases this involves ATP-mediated closure of K ATP null channels. To understand the relevance of this, we are...
Paper Details
Title
Glucose Stimulation of Hypothalamic MCH Neurons Involves KATP Channels, is Modulated by UCP2, and Regulates Peripheral Glucose Homeostasis
Published Date
Nov 3, 2010
Volume
12
Issue
5
Pages
545 - 552
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