Abstract 2567: Genetic risk stratification for breast cancer based on a polygenic risk score and family history.

Background: Breast cancer is the most common cancer among Western women. Risk stratification of women can aid surveillance for and prevention of breast cancer. However, the value of genetic profiling in risk stratification has been widely debated. Early studies were based on risk profiles generated from only a few genetic variants, while recent genome-wide association studies (GWAS) have led to the identification of many more loci. We...