The roles of senescence and telomere shortening in cardiovascular disease
Abstract
Cellular senescence, defined as arrest during the cell cycle (G₀), is involved in the complex process of the biological ageing of tissues, organs, and organisms. Senescence is driven by many factors including oxidative stress, the DNA damage and repair response, inflammation, mitogenic signals, and telomere shortening. Telomeres are shortened by each cell division until a critical length is reached and dysfunction ensues. DNA-repair pathways are...
Paper Details
Title
The roles of senescence and telomere shortening in cardiovascular disease
Published Date
Mar 12, 2013
Journal
Volume
10
Issue
5
Pages
274 - 283
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