Platinum drugs binding to human serum albumin: Effect of non-steroidal anti-inflammatory drugs

In this report, we provide investigations about the effect of Sudlow's site I and II blockers on the platinum anticancer drugs binding. The effect of warfarin, aspirin, ibuprofen and meloxicam on the platinum binding to HSA has been investigated through gel-filtration chromatography, UV–vis, CD, fluorescence spectroscopy and the inductively coupled plasma atomic emission spectroscopy (ICP(AES)) method. The results confirm that the platinum...