Advances in using PARP inhibitors to treat cancer
Abstract
The poly (ADP-ribose) polymerase (PARP) family of enzymes plays a critical role in the maintenance of DNA integrity as part of the base excision pathway of DNA repair. PARP1 is overexpressed in a variety of cancers, and its expression has been associated with overall prognosis in cancer, especially breast cancer. A series of new therapeutic agents that are potent inhibitors of the PARP1 and PARP2 isoforms have demonstrated important clinical...
Paper Details
Title
Advances in using PARP inhibitors to treat cancer
Published Date
Mar 9, 2012
Journal
Volume
10
Issue
1
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Notes
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