Chondroitin sulphate inhibits connective tissue mast cells

Mast cells derive from the bone marrow and are responsible for the development of allergic and possibly inflammatory reactions. Mast cells are stimulated by immunoglobulin E (IgE) and specific antigen, but also by a number of neuropeptides such as neurotensin (NT), somatostatin or substance P (SP), to secrete numerous pro‐inflammatory molecules that include histamine, cytokines and proteolytic enzymes. Chondroitin sulphate, a major constituent...