The perinuclear actin cap in health and disease

We recently demonstrated the existence of a previously uncharacterized subset of actomyosin fibers that form the perinuclear actin cap, a cytoskeletal structure that tightly wraps around the nucleus of a wide range of somatic cells. Fibers in the actin cap are distinct from well-characterized, conventional actin fibers at the basal and cortical surfaces of adherent cells in their subcellular location, internal organization, dynamics, ability to...