Phytopharmacological overview of Tribulus terrestris

Published on Jan 1, 2014in Pharmacognosy Reviews
· DOI :10.4103/0973-7847.125530
Saurabh Chhatre1
Estimated H-index: 1
,
Tanuja Nesari1
Estimated H-index: 1
+ 2 AuthorsSadhana Sathaye12
Estimated H-index: 12
(Government of Maharashtra)
Abstract
Tribulus terrestris (family Zygophyllaceae), commonly known as Gokshur or Gokharu or puncture vine, has been used for a long time in both the Indian and Chinese systems of medicine for treatment of various kinds of diseases. Its various parts contain a variety of chemical constituents which are medicinally important, such as flavonoids, flavonol glycosides, steroidal saponins, and alkaloids. It has diuretic, aphrodisiac, antiurolithic, immunomodulatory, antidiabetic, absorption enhancing, hypolipidemic, cardiotonic, central nervous system, hepatoprotective, anti-inflammatory, analgesic, antispasmodic, anticancer, antibacterial, anthelmintic, larvicidal, and anticariogenic activities. For the last few decades or so, extensive research work has been done to prove its biological activities and the pharmacology of its extracts. The aim of this review is to create a database for further investigations of the discovered phytochemical and pharmacological properties of this plant to promote research. This will help in confirmation of its traditional use along with its value-added utility, eventually leading to higher revenues from the plant.
  • References (48)
  • Citations (52)
Cite
References48
Published on Aug 1, 1994in Indian Journal of Experimental Biology
Anand R1
Estimated H-index: 1
,
Patnaik Gk1
Estimated H-index: 1
+ 1 AuthorsB. N. Dhawan11
Estimated H-index: 11
51 Citations
Published on May 1, 2012in Journal of Immunology 4.54
Joa-Sub Oh7
Estimated H-index: 7
(Dankook University),
Seung Ho Baik1
Estimated H-index: 1
+ 2 AuthorsSeong Su Hong20
Estimated H-index: 20
Inflammation is involved in various diseases, including chronic inflammatory disease and arthritis. The inflammation induced by the production of cyclooxygenease (COX)-2 and inducible nitric oxide synthase (iNOS), which are important mediators of inflammation. In this study, we investigated the ethanol extract of Tribulus terrestris (ETT) inhibited expression of COX-2 and iNOS in lipopolysaccharide(LPS)- stimulated RAW264.7 cells. We observed that ETT significantly decreased release of NO produc...
4 Citations
Published on Dec 1, 1998in Bollettino chimico farmaceutico
Arcasoy Hb1
Estimated H-index: 1
,
Erenmemisoglu A2
Estimated H-index: 2
+ 2 AuthorsMurat Kartal28
Estimated H-index: 28
27 Citations
B. Baburao1
Estimated H-index: 1
,
G. Rajyalakshmi1
Estimated H-index: 1
+ 3 AuthorsB. Ganga Rao1
Estimated H-index: 1
Tribulus terrestris Linn is a herb of the family Zygophyllaceae, whose parts are known to be used as traditional herbal medicine to treat various aliments such as kidney infections. The methanol extract of Tribulus terrestris plant was screened for anti-inflammatory and antimicrobial activity. The methanolic extract showed a significant inhibition on the growth of Gram (+) and Gram (-) bacteria at concentrations of 200 8g/mL and 400 8g/mL, respectively. A dose dependent inhibition of rat paw vol...
13 Citations
Published on Jan 1, 2001in Journal of Chinese medicinal materials
M Li2
Estimated H-index: 2
,
W Qu2
Estimated H-index: 2
+ 3 AuthorsM Tu1
Estimated H-index: 1
4 Citations
Published on Jul 1, 1989
William Charles Evans1
Estimated H-index: 1
Part 1: Introduction Plants in medicine: the origins of pharmacognosy The scope and practice of pharmacognosy Plant nomenclature and taxonomy Part 2: The plant and animal kingdoms as sources of drugs Biological and geographical sources of drugs A taxonomic approach to the study of medicinal plants and animal-derived drugs Pharmacological activities of natural products Synergy and other interactions in phytomedicines Traditional plant medicines as a source of new drugs Discovering new lead compou...
1,087 Citations
Published on Jan 1, 1998in Journal of Chemical Ecology 2.42
Alain Louveaux6
Estimated H-index: 6
(University of Paris-Sud),
M. Jay1
Estimated H-index: 1
+ 1 AuthorsG. Roux1
Estimated H-index: 1
(University of Paris-Sud)
We examined how variability in phenolic metabolism of four closely related Tribulus taxa might affect palatability to Schistocerca gregaria. Plants were collected in the Mauritanian breeding areas of the locust. Eighteen flavonoids (caffeoyl derivatives, quercetin glycosides, including rutin, and kaempferol glycosides) were detected with high-performance liquid chromatography in leaf extracts. Principal component analysis (PCA) differentiated relative abundance of flavonoids of Tribulus terrestr...
17 Citations Source Cite
Published on Jan 1, 2002in Journal of Chinese medicinal materials
M Li2
Estimated H-index: 2
,
W Qu2
Estimated H-index: 2
+ 2 AuthorsC Tian2
Estimated H-index: 2
30 Citations
Published on Jan 1, 2007in Experimental Biology and Medicine 2.41
V. K. Neychev1
Estimated H-index: 1
,
Ekaterina Nikolova3
Estimated H-index: 3
+ 1 AuthorsVanyo Mitev9
Estimated H-index: 9
The objective of the study was to explore the influence of saponins derived from Tribulus terrestris L. (TT) on normal human skin fibroblasts and to compare it with their anticancer properties. In this study, [3H]thymidine incorporation and MTT to assess cell proliferation and viability, respectively, and immunoblotting and HPLC analysis to explore intracellular signal transduction pathways have been used. We found that TT caused a dose-dependent decrease in [3H]thymidine incorporation into the ...
26 Citations Source Cite
Cited By52
Published on Jan 8, 2014in Journal of Human Kinetics 1.17
Andrzej Pokrywka9
Estimated H-index: 9
,
Zbigniew Obmiński1
Estimated H-index: 1
+ 3 AuthorsRyszard Grucza1
Estimated H-index: 1
(Nicolaus Copernicus University in Toruń)
Herbal and nutritional supplements are more and more popular in the western population. One of them is an extract of an exotic plant, named Tribulus terrestris (TT). TT is a component of several supplements that are available over-the-counter and widely recommended, generally as enhancers of human vitality. TT is touted as a testosterone booster and remedy for impaired erectile function; therefore, it is targeted at physically active men, including male athletes. Based on the scientific literatu...
9 Citations Source Cite
Published on Jun 1, 2015in Phytotherapy Research 3.35
P. L. Reshma1
Estimated H-index: 1
(National Institute for Interdisciplinary Science and Technology),
V. S. Lekshmi1
Estimated H-index: 1
(National Institute for Interdisciplinary Science and Technology)
+ 1 AuthorsK.G. Raghu18
Estimated H-index: 18
(National Institute for Interdisciplinary Science and Technology)
Tribulus terrestris L. was evaluated for its cardioprotective property against myocardial ischemia in a cell line model. Initially, methanolic extract was prepared and subjected to sequential extraction with various solvents. The extract with high phenolic content (T. terrestris L. ethyl acetate extract–TTME) was further characterized for its chemical constituents and taken forward for evaluation against cardiac ischemia. HPLC analysis revealed the presence of phenolic compounds like caffeic aci...
4 Citations Source Cite
Published on Jan 1, 2015in Herba Polonica
Nishi Saxena1
Estimated H-index: 1
,
Ameeta Argal1
Estimated H-index: 1
Urolithiasis is the process of formation of stone in the urinary tract by crystal nucleation, aggregation and retention in the urinary tract. Traditional medicinal plants have been successfully used to overcome urolithiasis. Hence, herbal formulation containing a mixture of plant extracts was prepared and evaluated for the antiurolithiatic activity. This formulation contained alcoholic extracts of fruit of Tribulus terrestris, root of Boerhavia diffusa and leaves of Azadirachta indica . Studies ...
2 Citations Source Cite
Published on Feb 29, 2016in PLOS ONE 2.77
Desislava Abadjieva2
Estimated H-index: 2
(Bulgarian Academy of Sciences),
E. Kistanova4
Estimated H-index: 4
(Bulgarian Academy of Sciences)
Although previous research has demonstrated the key role of the oocyte-derived factors, bone morphogenetic protein (BMP) 15 and growth differentiation factor (GDF) 9, in follicular development and ovulation, there is a lack of knowledge on the impact of external factors, which females are exposed to during folliculogenesis, on their expression. The present study investigated the effect of the aphrodisiac Tribulus terrestris on the GDF9 and BMP15 expression in the oocytes and cumulus cells at mRN...
5 Citations Source Cite
Published on May 1, 2015in Maturitas 3.31
Zdravko Kamenov4
Estimated H-index: 4
,
Svetlana Fileva1
Estimated H-index: 1
+ 1 AuthorsEmmanuele A. Jannini51
Estimated H-index: 51
(University of Rome Tor Vergata)
Abstract Objective The primary objectives were to compare the efficacy of extracts of the plant Tribulus terrestris (TT; marketed as Tribestan), in comparison with placebo, for the treatment of men with erectile dysfunction (ED) and with or without hypoactive sexual desire disorder (HSDD), as well as to monitor the safety profile of the drug. The secondary objective was to evaluate the level of lipids in blood during treatment. Participants and design Phase IV, prospective, randomized, double-bl...
10 Citations Source Cite
Published on May 1, 2016in Life Sciences 3.23
P.L. Reshma1
Estimated H-index: 1
(National Institute for Interdisciplinary Science and Technology),
Neethu S. Sainu1
Estimated H-index: 1
(National Institute for Interdisciplinary Science and Technology)
+ 1 AuthorsK.G. Raghu1
Estimated H-index: 1
(National Institute for Interdisciplinary Science and Technology)
Abstract Aims The present study investigates the protective effect of partially characterized Tribulus terrestris L. fruit methanol extract against mitochondrial dysfunction in cell based (H9c2) myocardial ischemia model. Main methods To induce ischemia, the cells were maintained in an ischemic buffer (composition in mM − 137 NaCl, 12 KCl, 0.5 MgCl 2 , 0.9 CaCl 2 , 20 HEPES, 20 2-deoxy- d -glucose, pH − 6.2) at 37 °C with 0.1% O 2 , 5% CO 2, and 95% N 2 in a hypoxia incubator for 1 h. Cells were...
12 Citations Source Cite
Published on Jan 1, 2016in International Journal of Impotence Research 1.52
M Campanelli1
Estimated H-index: 1
,
R De Thomasis1
Estimated H-index: 1
,
R L Tenaglia1
Estimated H-index: 1
A 36-year-old Caucasian man was diagnosed with a 72-h-lasting priapism that occurred after the assumption of a Herbal supplement based on Tribulus terrestris, which is becoming increasingly popular for the treatment of sexual dysfunction. The patient underwent a cavernoglandular shunt (Ebbehoj shunt) in order to obtain complete detumescence, from which derived negative post-episode outcomes on sexual function. All patients consuming non-FDA-approved alternative supplements such as Tribulus terre...
5 Citations Source Cite
Published on Jun 1, 2017in Andrologia 1.59
R. M. Salgado1
Estimated H-index: 1
,
M. H. Marques-Silva1
Estimated H-index: 1
+ 3 AuthorsP. Wolff1
Estimated H-index: 1
Summary Male fertility can be evaluated through complete semen analysis. Plants belonging to the Tribulus genus are known for their role in enhancing sex hormone levels and semen quality. The aim of this study was to evaluate the effects of T. terrestris on semen quality and physiological parameters. Sixty-five men with abnormal semen evaluation were included in this study, in which they were prescribed with oral administration of Androsten® (250 mg of Tribulus terrestris dried extract per capsu...
5 Citations Source Cite
Published on Nov 1, 2016in Canadian Journal of Physiology and Pharmacology 2.21
Liang Yin1
Estimated H-index: 1
,
Qian Wang1
Estimated H-index: 1
+ 1 AuthorsLiang-Nian Song1
Estimated H-index: 1
The objective of this study was to determine the effects of Tribulus terrestris L. (TT) saponins on exercise performance and the underlying mechanisms. A rat overtraining model was established and animals were treated with TT extracts (120 mg/kg body mass) 30 min before each training session. Serum levels of testosterone and corticosterone and levels of androgen receptor (AR) and insulin growth factor-1 receptor (IGF-1R) in the liver, gastrocnemius, and soleus were determined by ELISA and Wester...
6 Citations Source Cite
Published on Jun 1, 2016in Herba Polonica
Sara Batoei1
Estimated H-index: 1
,
Mohaddese Mahboubi10
Estimated H-index: 10
,
Reza Yari1
Estimated H-index: 1
1 Citations Source Cite