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Phytopharmacological overview of Tribulus terrestris

Published on Jan 1, 2014in Pharmacognosy Reviews
· DOI :10.4103/0973-7847.125530
Saurabh Chhatre1
Estimated H-index: 1
,
Tanuja Nesari1
Estimated H-index: 1
+ 2 AuthorsSadhana Sathaye12
Estimated H-index: 12
(Government of Maharashtra)
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Abstract
Tribulus terrestris (family Zygophyllaceae), commonly known as Gokshur or Gokharu or puncture vine, has been used for a long time in both the Indian and Chinese systems of medicine for treatment of various kinds of diseases. Its various parts contain a variety of chemical constituents which are medicinally important, such as flavonoids, flavonol glycosides, steroidal saponins, and alkaloids. It has diuretic, aphrodisiac, antiurolithic, immunomodulatory, antidiabetic, absorption enhancing, hypolipidemic, cardiotonic, central nervous system, hepatoprotective, anti-inflammatory, analgesic, antispasmodic, anticancer, antibacterial, anthelmintic, larvicidal, and anticariogenic activities. For the last few decades or so, extensive research work has been done to prove its biological activities and the pharmacology of its extracts. The aim of this review is to create a database for further investigations of the discovered phytochemical and pharmacological properties of this plant to promote research. This will help in confirmation of its traditional use along with its value-added utility, eventually leading to higher revenues from the plant.
  • References (48)
  • Citations (55)
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References48
Newest
Published on Aug 1, 2012
Tarek M.Y. El-Sheikh2
Estimated H-index: 2
,
Hanan A. M. B Bosly1
Estimated H-index: 1
,
Naglaa M. Shalaby3
Estimated H-index: 3
Methanolic extracts of leaves and seeds from, Tribulus terrestris (Zygophyllaceae) was tested against 3 rd instar larvae and adults of mosquito, Anopheles arabiensis under laboratory condition. The seeds extract showed high insecticidal activity at all concentrations compared to the leaves extract and the Lc50 was 36.5 and 123.1ppm for seeds and leaves extract, respectively. All extracts exhibited remarkable effects on the fecundity, fertility and sterility index of adult females resulted from t...
8 Citations Source Cite
Published on Jul 1, 2012in Protein and Peptide Letters 1.17
Anshu Aggarwal5
Estimated H-index: 5
,
Simran Tandon7
Estimated H-index: 7
+ 1 AuthorsChanderdeep Tandon14
Estimated H-index: 14
Adhesion of calcium oxalate (CaOx) crystals to kidney cells is a key event in kidney stones associated with marked hyperoxaluria. As the propensity of stone recurrence and persistent side effects are not altered by surgical techniques available, phytotherapeutic agents could be useful as an adjuvant therapy. The present study is aimed at examining the antilithiatic potency of the protein biomolecules of Tribulus terrestris, a plant which is a common constituent of herbal marketed preparations to...
18 Citations Source Cite
Published on May 1, 2012in Journal of Immunology 4.72
Joa-Sub Oh8
Estimated H-index: 8
(DU: Dankook University),
Seung Ho Baik1
Estimated H-index: 1
+ 2 AuthorsSeong Su Hong20
Estimated H-index: 20
Inflammation is involved in various diseases, including chronic inflammatory disease and arthritis. The inflammation induced by the production of cyclooxygenease (COX)-2 and inducible nitric oxide synthase (iNOS), which are important mediators of inflammation. In this study, we investigated the ethanol extract of Tribulus terrestris (ETT) inhibited expression of COX-2 and iNOS in lipopolysaccharide(LPS)- stimulated RAW264.7 cells. We observed that ETT significantly decreased release of NO produc...
4 Citations
Published on May 1, 2012in In Vitro Cellular & Developmental Biology – Animal 1.65
P. Kavitha4
Estimated H-index: 4
(BDU: Bharathidasan University),
R. Ramesh5
Estimated H-index: 5
(BDU: Bharathidasan University),
P. Subramanian7
Estimated H-index: 7
(BDU: Bharathidasan University)
Tribulus terrestris is a traditionally known non-toxic aphrodisiac herb for maleness. It was experimented recently to understand the effect and mechanism on mono sex production in Poecilia latipinna. It would help to develop a new eco-friendly way to masculinize P. latipinna, since males have higher commercial value than females. The different concentration (100, 150, 200, 250 and 300 mg/L) of T. terrestris extract and a control were tested for their effect on sex transformation/reversal in P. l...
4 Citations Source Cite
Surender Singh25
Estimated H-index: 25
(AIIMS: All India Institute of Medical Sciences),
Vinod Nair9
Estimated H-index: 9
(AIIMS: All India Institute of Medical Sciences),
Yogendra Kumar Gupta34
Estimated H-index: 34
(AIIMS: All India Institute of Medical Sciences)
Objectives: To study the effect of acute and repeated dose administration of lyophilized aqueous extract of the dried fruits of Tribulus terrestris (LAET) on sexual function in sexually sluggish male albino rats. Materials and Methods: Aphrodisiac activity of the test drug was evaluated in terms of exhibited sexual behavior. In order to assess the effect of chronic T. terrestris exposure on the hypothalamus--pituitary--gonadal axis, testosterone level estimation and sperm count were carried out....
34 Citations Source Cite
Published on Dec 1, 2011in In Vitro Cellular & Developmental Biology – Animal 1.65
P. Kavitha4
Estimated H-index: 4
(BDU: Bharathidasan University),
R. Ramesh5
Estimated H-index: 5
(BDU: Bharathidasan University)
+ 2 AuthorsP. Subramanian7
Estimated H-index: 7
(BDU: Bharathidasan University)
The potential protective role of Tribulus terrestris in acetaminophen-induced hepatotoxicity in Oreochromis mossambicus was investigated. The effect of oral exposure of acetaminophen (500 mg/kg) in O. mossambicus at 24-h duration was evaluated. The plant extract (250 mg/kg) showed a remarkable hepatoprotective activity against acetaminophen-induced hepatotoxicity. It was judged from the tissue-damaging level and antioxidant levels in liver, gill, muscle and kidney tissues. Further acetaminophen ...
35 Citations Source Cite
Published on Nov 21, 2011in African Journal of Biotechnology
Anita Tilwari1
Estimated H-index: 1
,
P Uma Devi1
Estimated H-index: 1
,
Vigyan Bhawan1
Estimated H-index: 1
Today, the use (which we can say ‘return to nature’) of traditional herbal medicines, herbal health products, pharmaceuticals food supplement, cosmetics, etc. is increasing due to the growing recognition that natural products are safe; have either no or negotiable side effects. The objective of this study was to investigate the immunomodulatory properties of five different medicinal plants used in Indian system of medicines on the Wistar rats. The activity was investigated by phagocytic carbon c...
14 Citations Source Cite
Shazia Khan5
Estimated H-index: 5
(Jamia Hamdard),
H. Kabir1
Estimated H-index: 1
(Jamia Hamdard)
+ 2 AuthorsKamran Javed Naquvi5
Estimated H-index: 5
(Jamia Hamdard)
The aqueous extract of fruits of Tribulus terrestris was tested for its effect on cholesterol induced hyperlipidaemia in rats. The study with aqueous extract at dose of 580 mg/kg body weight showed significant reduction in various biochemical parameters (LDL, VLDL, TC, TG &AI) and increase in HDL level than aqueous extract at dose of 300 mg/kg body weight.
4 Citations Source Cite
Published on Jul 1, 2011in International Journal of Biological Macromolecules 4.78
A.L. Shirfule1
Estimated H-index: 1
(Swami Ramanand Teerth Marathwada University),
A.T. Sangamwar1
Estimated H-index: 1
,
C.N. Khobragade11
Estimated H-index: 11
(Swami Ramanand Teerth Marathwada University)
Abstract Glycolate oxidase (GOX) is one of the principal enzymes involved in the pathway of oxalate synthesis. It converts glycolate to glyoxylate by oxidation and then glyoxylate is finally converted to oxalate. Therapeutic intervention of GOX in this consequence thus found potential in the treatment of calcium oxalate urolithiasis. In present investigation, we explored GOX in search of potential leads from traditional resources. Molecular modeling of the identified leads, quercetin and kaemphe...
14 Citations Source Cite
Published on Jun 1, 2011in Journal of Ethnopharmacology 3.41
Hye Jin Kim9
Estimated H-index: 9
(CNU: Chungnam National University),
Jin Chul Kim5
Estimated H-index: 5
(CNU: Chungnam National University)
+ 5 AuthorsJeong Keun Ahn7
Estimated H-index: 7
(CNU: Chungnam National University)
Abstract Ethnopharmacological relevance A medicinal herb Tribulus terrestris Linn has been used to treat various diseases including hepatocellular carcinoma. The aim of the present study was to investigate the anticancer activity of Tribulus terrestris Linn (TT) in liver cancer cells. Materials and methods The antitumor activity of aqueous TT extract was analyzed by testing the cytotoxicity and the effect on clonogenecity in HepG2 cells. Apoptosis and cell cycle arrest induced by TT were dissect...
29 Citations Source Cite
Cited By55
Newest
Harlokesh Narayan Yadav (AIIMS: All India Institute of Medical Sciences), Uma Shankar Sharma (AIIMS: All India Institute of Medical Sciences)+ 1 AuthorsYogendra Kumar Gupta34
Estimated H-index: 34
(AIIMS: All India Institute of Medical Sciences)
Mercury generates free radicals and oxidative stress which are associated with renal injury. Tribulus terrestris (TT), Boerhavia diffusa (BD), and Terminalia chebula (TC) have anti-inflammatory and antioxidant properties. Hydroalcoholic extract of combination of TT, BD and TC were evaluated against mercuric chloride induced nephrotoxicity. Rats (n = 6) were treated with combination of TT, BD and TC in three different doses (198, 300 and 600 mg/kg) of equal ratio of each drug and Combination per ...
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Published on May 1, 2019in Neurochemical Research 2.78
R. Ranjithkumar , Qasim Alhadidi5
Estimated H-index: 5
(UT: University of Toledo)
+ 1 AuthorsMuthiah Ramanathan
The present study has been aimed to explore the different secondary messengers of the inflammatory pathway NF-κB, kinases (JNK, P38MAPK, GSK3β/βcatenin), apoptosis pathway (Caspase-3 and AIF), and neuronal survival pathway (BDNF) in order to understand the neuroprotective mechanism of aqueous extract of Tribulus terrestris (AQTT). In primary cortical neurons, the ischemic condition was induced through oxygen–glucose deprivation (OGD). Anti-inflammatory activity of AQTT was evaluated in formalin ...
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Published on May 1, 2019in Journal of Ethnopharmacology 3.41
Heitor O. Santos2
Estimated H-index: 2
(UFU: Federal University of Uberlandia),
Scott L. Howell , Filipe J. Teixeira1
Estimated H-index: 1
(University of Lisbon)
Abstract Ethno-pharmacological relevance Phytotherapeutic approaches have been widely proposed to improve male health. Despite the well-touted effects of tribulus (Tribulus terrestris L) on men's health, an optimal phytotherapy remains an elusive challenge. Aim of the review We sought to critically analyze the evidence in the phytotherapic literature beyond the effects of tribulus on testosterone (T) concentration and sperm analysis to also include indications for prostate health. Materials and ...
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Published on Apr 26, 2019
Rohit Sharma4
Estimated H-index: 4
,
Natália Martins + 4 AuthorsPradeep Kumar Prajapati4
Estimated H-index: 4
Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs and their extracts, including the prime ingredient, Amla (Indian gooseberry), which is the world’s richest source of vitamin C. Chyawanprash preparatio...
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Published on Apr 1, 2019
Mohammed A. H. Dhaif Allah (University of Mysore), Syed Noeman Taqui2
Estimated H-index: 2
(UM: University of Malaya)
+ 1 AuthorsAkheel Ahmed Syed13
Estimated H-index: 13
(University of Mysore)
First-ever study was done using a low-cost Tribulus terrestris spent, a by-product of a nutraceutical industry as an effective biosorbent for removing acid blue 113 (AB113) from aqueous media. The effect of various factors such as pH, dye concentration, amount of adsorbent, particle size of adsorbent, contact time as also temperature on adsorption have been studied. Analysis of equilibrium data was done by using two number of two-parameter and six number of three-parameter isotherm models. Kinet...
1 Citations Source Cite
Published on Apr 1, 2019in Inflammopharmacology 3.84
Muhammad Daniyal2
Estimated H-index: 2
(Hunan University),
Muhammad Akram8
Estimated H-index: 8
(GCUF: Government College University, Faisalabad)
+ 5 AuthorsWang Wei92
Estimated H-index: 92
(Hunan University)
Background Herbal medicine plays an important role in health, particularly in remote parts of developing areas with few health facilities. According to WHO estimates, about three-quarters of the world's population currently use herbs or traditional medicines to treat various ailments, including liver diseases. Several studies have found that the use of medicinal plants was effective in the treatment of infectious and non-infectious diseases. Hepatitis and liver cirrhosis associated with many cli...
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Abdul Waheed Khan (UOL: University of Lahore), Arif-ullah Khan21
Estimated H-index: 21
(Riphah International University)
+ 3 AuthorsMuhammad Saleem2
Estimated H-index: 2
(Riphah International University)
Background. Almost every region of Pakistan is stacked with a large number of medicinal plants. Due to high cost and unavailability of allopathic medicines for the neurological diseases, especially in rural areas, traditional healers prescribe phytotherapy for various neurological diseases like epilepsy, depression, anxiety, insomnia, Alzheimer, and migraine. Such treatments are considered to be most effective by the native people. Methods. The data was collected from articles published on medic...
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Published on Mar 1, 2019in Experimental Parasitology 1.72
Abdur Rehman3
Estimated H-index: 3
(AMU: Aligarh Muslim University),
Rizwan Ullah4
Estimated H-index: 4
(AMU: Aligarh Muslim University)
+ 3 AuthorsS. M. A. Abidi7
Estimated H-index: 7
(AMU: Aligarh Muslim University)
Abstract In order to ensure global food security a rationale approach is required to control all those factors which directly or indirectly affect the food productivity. The neglected helminthic diseases alone are responsible for huge economic losses to the agrarian stakeholders. The problem is further compounded by the emerging drug resistance in flukes against the commonly used anthelmintics like triclabendazole. Therefore, the search for alternatives including the nano-based approaches has be...
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