Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Abstract
During virus infection, the adaptor proteins MAVS and STING transduce signals from the cytosolic nucleic acid sensors RIG-I and cGAS, respectively, to induce type I interferons (IFNs) and other antiviral molecules. Here we show that MAVS and STING harbor two conserved serine and threonine clusters that are phosphorylated by the kinases IKK and/or TBK1 in response to stimulation. Phosphorylated MAVS and STING then bind to a positively charged...
Paper Details
Title
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Published Date
Mar 13, 2015
Journal
Volume
347
Issue
6227
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