Modeling and simulations of a bacterial outer membrane protein: OprF from Pseudomonas aeruginosa

OprF is a major outer membrane protein from Pseudomonas aeruginosa , a homolog of OmpA from Escherichia coli . The N‐terminal domains of both proteins have been demonstrated to form low conductance channels in lipid bilayers. Homology models, consisting of an eight‐stranded β‐barrel, of the N‐terminal domain OprF have been constructed based on the crystal structure of the corresponding domain from E . coli OmpA. OprF homology models have been...