Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors

Volume: 14, Issue: 5, Pages: 570 - 577
Published: Mar 27, 2011
Abstract
Developing skeletal myofibers in vertebrates are intrinsically 'pre-patterned' for motor nerve innervation. However, the intrinsic factors that regulate muscle pre-patterning remain unknown. We found that a functional skeletal muscle dihydropyridine receptor (DHPR, the L-type Ca(2+) channel in muscle) was required for muscle pre-patterning during the development of the neuromuscular junction (NMJ). Targeted deletion of the β1 subunit of DHPR...
Paper Details
Title
Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors
Published Date
Mar 27, 2011
Volume
14
Issue
5
Pages
570 - 577
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