High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery
Abstract
More general and universally applicable drug discovery assay technologies are needed in order to keep pace with the recent advances in combinatorial chemistry and genomics-based target generation. Ligand-induced conformational stabilization of proteins is a well-understood phenomenon in which substrates, inhibitors, cofactors, and even other proteins provide enhanced stability to proteins on binding. This phenomenon is based on the energetic...
Paper Details
Title
High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery
Published Date
Dec 1, 2001
Journal
Volume
6
Issue
6
Pages
429 - 440
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Notes
History