Cell proliferation inhibition and antitumor activity of novel alkyl series of diorganotin(IV) compounds

Diorganotin(IV) compounds, R 2 SnCl 2 are often tetrahedral, and structurally resemble the active platinum compounds, i.e. cisplatin, and consequently a large number of such complexes have been tested for antitumor activity. A structural correlation with biological activity for diorganotin(IV) complexes has shown that active species are associated with complexes having Sn–N bonds longer than 2.39 Å which in turn determines the formation of a...