Topical application of the tumour necrosis factor‐α antibody infliximab improves healing of chronic wounds

The role of tumour necrosis factor‐alpha (TNF‐α) in wound healing is not clear. Elevated levels of TNF‐α have been observed in fluids from chronic wounds and have been shown to decrease over time during the healing process. Therapeutic antibodies such as infliximab can inhibit TNF‐α activity. In this case series, we applied infliximab topically to eight patients with chronic ulcers of more than 4‐month durations. The ulcers had multifactorial...