Tandem Mass Spectrometry Newborn Screening and Its Impact on Inborn Errors of Metabolism

The adaptation of the analytical technique, tandem mass spectrometry (MS/MS), as a tool to screen blood samples from newborns for markers suggestive of certain rare inborn errors of metabolism (IEM) has had a significant impact on the early diagnosis and successful treatment of these disorders. It is important for professionals in the field of IEM to realize the limitations, as well as the power, of this methodology when applied to newborn...