Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy
Abstract
Diabetes is characterized by "glucotoxic" loss of pancreatic β cell function and insulin content, but underlying mechanisms remain unclear. A mouse model of insulin-secretory deficiency induced by β cell inexcitability (K(ATP) gain of function) demonstrates development of diabetes and reiterates the features of human neonatal diabetes. In the diabetic state, β cells lose their mature identity and dedifferentiate to neurogenin3-positive and...
Paper Details
Title
Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy
Published Date
May 1, 2014
Journal
Volume
19
Issue
5
Pages
872 - 882
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