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Genetics of Alcohol Dependence and Social Work Research: Do They Mix?

Published on May 1, 2013in Social Work in Public Health 0.65
· DOI :10.1080/19371918.2013.758999
Michie N. Hesselbrock26
Estimated H-index: 26
(UConn: University of Connecticut),
Victor Hesselbrock72
Estimated H-index: 72
(UConn: University of Connecticut),
Karen G. Chartier11
Estimated H-index: 11
(University of Texas at Austin)
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Abstract
Since completion of the mapping of the human genome in early 2000, tremendous progress has been made in the identification of many different genes associated with our health and across diseases. Although social work researchers are not expected to conduct genetic research at the molecular level, it is imperative that we are able to understand the basic genetic findings related to behavioral problems and are able to translate and integrate this information into psychosocial treatment approaches and program development. This article is an introduction and overview of genetic approaches, using studies of the genetics of alcoholism to exemplify important issues. The literature review is not comprehensive and focuses primarily on the Collaborative Study on the Genetics of Alcoholism project as an example of a multidisciplinary and integrative approach to the genetic study of a major health problem often encountered in social work practice.
  • References (82)
  • Citations (4)
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References82
Newest
Published on Apr 12, 2012in PLOS ONE 2.78
Aaron R. Wolen14
Estimated H-index: 14
(VCU: Virginia Commonwealth University),
Charles A. Phillips8
Estimated H-index: 8
(UT: University of Tennessee)
+ 6 AuthorsMichael F. Miles23
Estimated H-index: 23
(VCU: Virginia Commonwealth University)
Background Individual differences in initial sensitivity to ethanol are strongly related to the heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate ethanol sensitivity we performed the first systems genetics analysis of ethanol-responsive gene expression in brain regions of the mesocorticolimbic reward circuit (prefrontal cortex, nucleus accumbens, and ventral midbrain) across a highly diverse family of 27 isogenic mouse strains (BXD panel) before and after ...
Published on Jan 1, 2012in Behavior Genetics 2.31
Jenny H. D. A. van Beek10
Estimated H-index: 10
(VU: VU University Amsterdam),
Kenneth S. Kendler152
Estimated H-index: 152
(MCV: VCU Medical Center)
+ 6 AuthorsDorret I. Boomsma126
Estimated H-index: 126
(VU: VU University Amsterdam)
Relatively little is known about how genetic influences on alcohol abuse and dependence (AAD) change with age. We examined the change in influence of genetic and environmental factors which explain symptoms of AAD from adolescence into early adulthood. Symptoms of AAD were assessed using the four AAD screening questions of the CAGE inventory. Data were obtained up to six times by self-report questionnaires for 8,398 twins from the Netherlands Twin Register aged between 15 and 32 years. Longitudi...
Published on Jan 1, 2012in Families, Systems, & Health 1.32
Allison Werner-Lin11
Estimated H-index: 11
(NYU: New York University),
Lisa R. Rubin15
Estimated H-index: 15
(The New School)
+ 4 AuthorsMichal Sagi23
Estimated H-index: 23
Deleterious mutations in the BRCA1/BRCA2 genes elevate lifetime risk of breast and ovarian cancer. Each child of a mutation-positive parent has a 50% chance of inheriting it. Preimplantation genetic diagnosis (PGD) permits prospective parents to avoid the birth of a BRCA-mutation-positive child, introducing predictability into a process historically defined by chance. This investigation explored how BRCA1/2 mutation carriers understand genetic inheritance and consider a child’s inheritance of a ...
Published on Dec 1, 2011in Alcoholism: Clinical and Experimental Research 3.23
Danielle M. Dick58
Estimated H-index: 58
(VCU: Virginia Commonwealth University),
Jacquelyn L. Meyers15
Estimated H-index: 15
+ 2 AuthorsKenneth S. Kendler152
Estimated H-index: 152
Alcohol dependence is under substantial genetic influence (Dick et al., 2009), and twin studies demonstrate that measures of alcohol consumption (AC) are under significant genetic influence as well (Dick and Bierut, 2006; Goldman, 1993; Prescott and Kendler, 1999; Rose, 1998). That evidence has fostered studies investigating the extent to which the same genetic factors underlie patterns of consumption and the development of problems. Data from the Australian twin registry indicated moderate corr...
Published on Jan 1, 2010in American Journal of Medical Genetics
Danielle M. Dick58
Estimated H-index: 58
(VCU: Virginia Commonwealth University),
Jacquelyn L. Meyers15
Estimated H-index: 15
(VCU: Virginia Commonwealth University)
+ 11 AuthorsTatiana Foroud101
Estimated H-index: 101
(IU: Indiana University)
Twin studies provide strong evidence that there is a shared genetic liability that predisposes to a number of different psychiatric outcomes related to behavioral disinhibition. Further, alcohol dependence comorbid with other disinhibitory disorders is particularly heritable. Chromosome 2p14–2q14.3 has been linked to multiple psychiatric conditions related to behavioral undercontrol. In the Collaborative Study on the Genetics of Alcoholism (COGA), we previously reported linkage to this region wi...
Published on May 1, 2009in Journal of Studies on Alcohol and Drugs 2.58
Marc A. Schuckit94
Estimated H-index: 94
(UCSD: University of California, San Diego),
Thomas L. Smith60
Estimated H-index: 60
(UCSD: University of California, San Diego)
+ 6 AuthorsDanielle M. Dick58
Estimated H-index: 58
(VCU: Virginia Commonwealth University)
Objective: The low level of response (LR) to alcohol is an endophenotype related to heavier drinking and alcohol problems. Structural equation models (SEMs) indicate LR affects alcohol outcomes (ALCOUT) both directly and through mediation by drinking in peers (PEER), alcohol expectancies (EXPECT), and drinking to cope with stress (COPE), with some variation depending on the sample tested. This article presents the first full test of this LR-based model in young subjects from the Collaborative St...
Published on Jul 1, 2008in Addiction 6.85
Arpana Agrawal48
Estimated H-index: 48
(WashU: Washington University in St. Louis),
Michael T. Lynskey85
Estimated H-index: 85
(WashU: Washington University in St. Louis)
Aims In this exciting era of gene discovery, we review evidence from family, adoption and twin studies that examine the genetic basis for addiction. With a focus on the classical twin design that utilizes data on monozygotic and dizygotic twins, we discuss support in favor of heritable influences on alcohol, nicotine, cannabis and other illicit drug dependence. Methods We review whether these genetic factors also influence earlier stages (e.g. experimentation) of the addictive process and whethe...
Published on Jun 2, 2008in Archives of General Psychiatry
Kenneth S. Kendler152
Estimated H-index: 152
,
Eric Schmitt1
Estimated H-index: 1
+ 1 AuthorsCarol A. Prescott64
Estimated H-index: 64
Context While both environmental and genetic factors are important in the etiology of psychoactive substance use (PSU), we know little of how these influences differ through development. Objective To clarify the changing role of genes and environment in PSU from early adolescence through middle adulthood. Design Retrospective assessment by life history calendar, with univariate and bivariate structural modeling. Setting General community. Participants A total of 1796 members of male-male pairs f...
Published on Feb 1, 2008in Journal of Psychiatric Research 3.92
Michael Soyka42
Estimated H-index: 42
(LMU: Ludwig Maximilian University of Munich),
Ulrich W. Preuss31
Estimated H-index: 31
(LMU: Ludwig Maximilian University of Munich)
+ 3 AuthorsBrigitta Bondy47
Estimated H-index: 47
(LMU: Ludwig Maximilian University of Munich)
Abstract Gamma-aminobutyric acid (GABA) A receptors are believed to mediate some of the physiological and behavioral actions of ethanol. Recent studies have suggested that genetic variants of the GABA-A receptor alpha2 subunit gene (GABRA2) are associated with alcohol dependence. The aim of this study is to confirm and extend the role of GABRA2 haplotypes in the liability to alcohol dependence. 291 (231 male) treatment-seeking alcohol-dependent individuals and 295 (153 male) control subjects wer...
Cited By4
Newest
Published on Feb 1, 2018in Research on Social Work Practice 1.27
Brandy R. Maynard17
Estimated H-index: 17
(SLU: Saint Louis University),
Brian B. Boutwell21
Estimated H-index: 21
(SLU: Saint Louis University)
+ 2 AuthorsNathaniel A. Dell3
Estimated H-index: 3
(SLU: Saint Louis University)
Background:Despite an emphasis on a biopsychosocial understanding of human behavior and the relevance of biosocial research to social work practice, it is unclear whether social work is contributing to biosocial research and knowledge.Methods:Systematic review procedures were employed to locate studies that included biological variables (e.g., genetic or physiological factors) related to behavior and were published in a social work journal between 2000 and 2015. Seventy-five social work journals...
Published on Jul 1, 2017in British Journal of Social Work 1.57
Brandy R. Maynard17
Estimated H-index: 17
(SLU: Saint Louis University),
Brian B. Boutwell21
Estimated H-index: 21
(SLU: Saint Louis University),
Michael G. Vaughn41
Estimated H-index: 41
(SLU: Saint Louis University)
Addiction is a multifaceted condition with various entry and exit points throughout its course in an individual's life. In some adolescents, early onset can be followed by limited adolescent use or abuse and is more related to social risk factors especially in socialized adolescents. On the other hand, if the early onset use leads to addiction beyond adolescence, the chances are high there are interpersonal contributing factors and possibly a difficult or problematic adolescent stage. This paper...