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References13
Newest
Published on Feb 1, 2010in Lancet Neurology28.75
Charlotte J.J. van Asch6
Estimated H-index: 6
,
Merel J A Luitse12
Estimated H-index: 12
+ 3 AuthorsCatharina J.M. Klijn34
Estimated H-index: 34
Summary Background Since the early 1980s, imaging techniques have enabled population-based studies of intracerebral haemorrhage. We aimed to assess the incidence, case fatality, and functional outcome of intracerebral haemorrhage in relation to age, sex, ethnic origin, and time period in studies published since 1980. Methods From PubMed and Embase searches with predefined inclusion criteria, we identified population-based studies published between January, 1980, and November, 2008. We calculated...
Published on Mar 1, 2009in Stroke6.05
Stephan A. Mayer68
Estimated H-index: 68
,
Stephen M. Davis Mpa Msw89
Estimated H-index: 89
+ 5 AuthorsThorsten Steiner48
Estimated H-index: 48
Background and Purpose— In the Factor Seven for Acute Hemorrhagic Stroke (FAST) trial, 80 μg/kg of recombinant activated factor VII (rFVIIa) significantly reduced intracerebral hemorrhage (ICH) expansion when given within 4 hours of onset. However, in contrast to an earlier Phase 2b study, rFVIIa did not improve survival or functional outcome. In this exploratory analysis, we hypothesized that earlier treatment and exclusion of patients with a poor prognosis at baseline might enhance the benefit...
Published on Oct 8, 2008in Cochrane Database of Systematic Reviews7.75
Kameshwar Prasad30
Estimated H-index: 30
(AIIMS: All India Institute of Medical Sciences),
A. David Mendelow30
Estimated H-index: 30
,
Barbara Gregson30
Estimated H-index: 30
Published on Jul 1, 2008in Stroke6.05
Natalia S. Rost35
Estimated H-index: 35
,
Steven M. Greenberg96
Estimated H-index: 96
,
Jonathan Rosand68
Estimated H-index: 68
Background and Purpose— Intracerebral hemorrhage (ICH), the acute manifestation of a common progressive cerebrovascular disease of the elderly, is the most fatal and least treatable form of stroke. There is a desperate need for ICH-specific therapeutics and effective primary prevention strategies, a need that is certain to grow with the aging of the population. Data point to a sizable genetic component to ICH susceptibility. Identification of ICH-related genes therefore holds promise for identif...
Published on May 1, 2008in Lancet Neurology28.75
Craig S. Anderson77
Estimated H-index: 77
(RPA: Royal Prince Alfred Hospital),
Yining Huang26
Estimated H-index: 26
(PKU: Peking University)
+ 17 AuthorsJong S. Kim46
Estimated H-index: 46
(Asan Medical Center)
Summary Background There is much uncertainty about the effects of early lowering of elevated blood pressure (BP) after acute intracerebral haemorrhage (ICH). Our aim was to assess the safety and efficiency of this treatment, as a run-in phase to a larger trial. Methods Patients who had acute spontaneous ICH diagnosed by CT within 6 h of onset, elevated systolic BP (150–220 mm Hg), and no definite indication or contraindication to treatment were randomly assigned to early intensive lowering of BP...
Published on Mar 1, 2008in Stroke6.05
Md. Shaheenul Islam1
Estimated H-index: 1
,
Craig S. Anderson77
Estimated H-index: 77
+ 4 AuthorsKonrad Jamrozik67
Estimated H-index: 67
Background and Purpose— We studied temporal trends in major stroke outcomes in Perth, Western Australia (WA), comparing 3 12-month periods, roughly 5 years apart, between 1989 and 2001. Methods— The Perth Community Stroke Study (PCSS) used uniform definitions and procedures in a representative segment (approximately 143 000 people in the year 2000) of Perth, WA. Crude and age-standardized incidence and 28-day case fatality for stroke in the different study periods were compared using Poisson reg...
Published on Jun 1, 2007in Lancet Neurology28.75
Caroline E. Lovelock9
Estimated H-index: 9
(University of Oxford),
Andy Molyneux13
Estimated H-index: 13
(University of Oxford),
Peter M. Rothwell106
Estimated H-index: 106
(University of Oxford)
Summary Background UK stroke mortality data suggest that the incidence of haemorrhagic stroke has fallen in the past 20 years, but these data do not include deaths of individuals aged 75 years or over. Trends in the older population might differ, since cause varies with age. Our aim was to investigate changes in the population-based incidence of intracerebral haemorrhage according to age and likely aetiology. Methods We used data from the Oxford Community Stroke Project (OCSP; 1981–86) and the O...
Published on Aug 23, 2005in Neurology8.69
Daniel L. Labovitz15
Estimated H-index: 15
,
A. Halim3
Estimated H-index: 3
(UVM: University of Vermont)
+ 2 AuthorsRalph L. Sacco123
Estimated H-index: 123
(Columbia University)
Background: Black and Hispanic Americans have a greater risk of primary intracerebral hemorrhage (ICH) than whites. Deep ICH is most often associated with hypertension, while lobar ICH is associated with cerebral amyloid angiopathy. The authors conducted a population-based incidence study to directly compare the incidence of deep vs lobar ICH in all three race-ethnic groups. Methods: The authors used an active hospital and community surveillance program and autopsy reports to identify incident I...
Published on Jun 1, 2004in The Lancet59.10
Peter M. Rothwell106
Estimated H-index: 106
(University of Oxford),
A J Coull3
Estimated H-index: 3
(University of Oxford)
+ 13 AuthorsCatherine Sackley32
Estimated H-index: 32
(University of Oxford)
Summary Background The incidence of stroke is predicted to rise because of the rapidly ageing population. However, over the past two decades, findings of randomised trials have identified several interventions that are effective in prevention of stroke. Reliable data on time-trends in stroke incidence, major risk factors, and use of preventive treatments in an ageing population are required to ascertain whether implementation of preventive strategies can offset the predicted rise in stroke incid...
Published on May 27, 2004in Stroke6.05
Chisato Nagata46
Estimated H-index: 46
(Gidai: Gifu University),
Naoyoshi Takatsuka25
Estimated H-index: 25
(Gidai: Gifu University)
+ 1 AuthorsHiroyuki Shimizu48
Estimated H-index: 48
(Gidai: Gifu University)
Background and Purpose— Despite the evidence for a positive association of dietary salt and blood pressure, the few prospective studies that have assessed the association between dietary salt and stroke have reported inconsistent results. The purpose of this study was to examine the relation between sodium intake and death from stroke in a population-based cohort of Japanese men and women. Methods— In 1992, usual diet including sodium intake was determined in 13 355 men and 15 724 women in Takay...
Cited By25
Newest
Published on Jan 13, 2019
Jieru Wan (Johns Hopkins University), Honglei Ren (Johns Hopkins University), Jianbo Wang55
Estimated H-index: 55
(Johns Hopkins University)
Intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity. However, we have few options for ICH therapy and limited knowledge about post-ICH neuronal death and related mechanisms. In the aftermath of ICH, iron overload within the perihaematomal region can induce lethal reactive oxygen species (ROS) production and lipid peroxidation, which contribute to secondary brain injury. Indeed, iron chelation therapy has shown efficacy in preclinical ICH studies. Rec...
Published on Mar 1, 2019in Free Radical Biology and Medicine5.66
Shashank Masaldan7
Estimated H-index: 7
(Florey Institute of Neuroscience and Mental Health),
Ashley I. Bush126
Estimated H-index: 126
(Florey Institute of Neuroscience and Mental Health)
+ 2 AuthorsCaroline Moreau28
Estimated H-index: 28
(French Institute of Health and Medical Research)
Abstract Perturbations in iron homeostasis and iron accumulation feature in several neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). Proteins such as α -synuclein, tau and amyloid precursor protein that are pathologically associated with neurodegeneration are involved in molecular crosstalk with iron homeostatic proteins. Quantitative susceptibility mapping, an MRI based non-invasive technique, offers proximal evalu...
Published on Aug 20, 2018in Frontiers in Neurology2.63
Qian-qian Li1
Estimated H-index: 1
(Zhengzhou University),
Lan-Jun Li1
Estimated H-index: 1
(Zhengzhou University)
+ 2 AuthorsJun Wu1
Estimated H-index: 1
(Zhengzhou University)
Intracerebral hemorrhage (ICH) is a fatal acute cerebrovascular disease, with a high morbidity and mortality. Following ICH, erythrocytes release heme and several of its metabolites, thereby contributing to brain edema and secondary brain damage. Heme oxygenase is the initial and rate-limiting enzyme of heme catabolism, and the expression of heme oxygenase-1 (HO-1) is rapidly induced following acute brain injury. As HO-1 exerts it effects via various metabolites, its role during ICH remains comp...
Published on Apr 6, 2017in JCI insight
Qian Li11
Estimated H-index: 11
,
Xiaoning Han13
Estimated H-index: 13
+ 11 AuthorsChao Jiang9
Estimated H-index: 9
Published on Apr 1, 2017in Molecular Neurobiology4.59
Zhen Zhang4
Estimated H-index: 4
(HMU: Harbin Medical University),
Ze Zhang2
Estimated H-index: 2
(HMU: Harbin Medical University)
+ 3 AuthorsJianbo Wang55
Estimated H-index: 55
(JHUSOM: Johns Hopkins University School of Medicine)
Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity. When a diseased artery within the brain bursts, expansion and absorption of the resulting hematoma trigger a series of reactions that cause primary and secondary brain injury. Microglia are extremely important for removing the hematoma and clearing debris, but they are also a source of ongoing inflammation. This article discusses the role of microglial activation/polarization and related inflammatory mediato...
Published on Mar 21, 2017in Brain Injury1.67
Hanjin Cui6
Estimated H-index: 6
(CSU: Central South University),
Hao-yu He2
Estimated H-index: 2
(CSU: Central South University)
+ 3 AuthorsJiekun Luo11
Estimated H-index: 11
(CSU: Central South University)
ABSTRACTObjective: Hyperbaric oxygen (HBO) is widely used in treating various neurological diseases. However, HBO for treatment of intracerebral haemorrhage (ICH) remains controversial, in either animal or clinical studies. Therefore, we conducted this systematic review and meta-analysis on studies describing the efficacy of HBO in animal models of ICH.Methods: Studies were identified by searching mainstream databases through November 2015. The efficacy of HBO in animal models of ICH was assesse...
Published on Jan 1, 2017in Neuroepidemiology2.69
Chung-Fen M. D. Tsai1
Estimated H-index: 1
,
Jiann-Shing Jeng34
Estimated H-index: 34
+ 1 AuthorsC. Sudlow45
Estimated H-index: 45
Background: Chinese populations have a higher stroke incidence, a higher proportion of intracerebral hemorrhage (ICH), and a lower proportion of ischemic stroke (
Published on Dec 1, 2016in Journal of Neuroinflammation5.70
Bo Ma7
Estimated H-index: 7
(UF: University of Florida),
Jason Day1
Estimated H-index: 1
(UF: University of Florida)
+ 3 AuthorsSylvain Doré44
Estimated H-index: 44
(UF: University of Florida)
Background Following intracerebral hemorrhage (ICH), red blood cells release massive amounts of toxic heme that causes local brain injury. Hemopexin (Hpx) has the highest binding affinity to heme and participates in its transport, while heme oxygenase 2 (HO2) is the rate-limiting enzyme for the degradation of heme. Microglia are the resident macrophages in the brain; however, the significance and role of HO2 and Hpx on microglial clearance of the toxic heme (iron-protoporphyrin IX) after ICH sti...
Published on Dec 1, 2016
Hanna C. Persson7
Estimated H-index: 7
(University of Gothenburg),
Arve Opheim8
Estimated H-index: 8
(University of Gothenburg)
+ 3 AuthorsKatharina Stibrant Sunnerhagen38
Estimated H-index: 38
(University of Gothenburg)
IntroductionThe purpose was to explore if there are differences in extent of change in upper extremity motor function and activity capacity, in persons with ischaemic versus haemorrhagic stroke, during the first year post stroke.Patients and methodsOne hundred seventeen persons with stroke (ischaemic n = 98, haemorrhagic n = 19) and reduced upper extremity function 3 days after onset were consecutively included to the Stroke Arm Longitudinal Study at the University of Gothenburg (SALGOT) from a ...
Published on May 23, 2016in PLOS ONE2.78
Mathieu Schertz2
Estimated H-index: 2
,
Hossein Mehdaoui1
Estimated H-index: 1
+ 3 AuthorsMehdi Mejdoubi8
Estimated H-index: 8
Background Incidence of spontaneous subarachnoid hemorrhages (SAH) varies wildly across the world and seems to be low in Central and South America (4.2 per 100 000 person-years; CI 95%; 3.1–5.7). The objective of our study was to describe the characteristics of SAH and to estimate its incidence and severity in Martinique, a small French island located in the Caribbean Sea. Methods Due to its insular nature and small captive population, Martinique is ideal for the setting up of population-based e...
View next paperIncidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis