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Intracerebral haemorrhage: a need for more data and new research directions

Published on Feb 1, 2010in Lancet Neurology28.755
· DOI :10.1016/S1474-4422(10)70001-6
Geoffrey A. Donnan100
Estimated H-index: 100
,
Graeme J. Hankey110
Estimated H-index: 110
(RPH: Royal Perth Hospital),
Stephen M. Davis Mpa Msw94
Estimated H-index: 94
(Royal Melbourne Hospital)
Abstract
  • References (14)
  • Citations (25)
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References14
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#2Merel J.A. LuitseH-Index: 12
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#1Stephan A. MayerH-Index: 71
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Background and Purpose— In the Factor Seven for Acute Hemorrhagic Stroke (FAST) trial, 80 μg/kg of recombinant activated factor VII (rFVIIa) significantly reduced intracerebral hemorrhage (ICH) expansion when given within 4 hours of onset. However, in contrast to an earlier Phase 2b study, rFVIIa did not improve survival or functional outcome. In this exploratory analysis, we hypothesized that earlier treatment and exclusion of patients with a poor prognosis at baseline might enhance the benefit...
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#1Kameshwar Prasad (AIIMS: All India Institute of Medical Sciences)H-Index: 30
#2A. David MendelowH-Index: 30
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BACKGROUND:There is considerable international variation in the rate and indications of surgery for primary supratentorial intracerebral haematoma, reflecting the uncertainty about the effects of surgery. Recently, some large randomised trials have appeared in the literature but the controversy over its role continues. This is an update of a Cochrane review first published in 1997, and previously updated in 1999. OBJECTIVES:To assess the effects of surgery plus routine medical management, compar...
106 CitationsSource
#1Natalia S. RostH-Index: 38
#2Steven M. GreenbergH-Index: 98
Last. Jonathan RosandH-Index: 70
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Background and Purpose— Intracerebral hemorrhage (ICH), the acute manifestation of a common progressive cerebrovascular disease of the elderly, is the most fatal and least treatable form of stroke. There is a desperate need for ICH-specific therapeutics and effective primary prevention strategies, a need that is certain to grow with the aging of the population. Data point to a sizable genetic component to ICH susceptibility. Identification of ICH-related genes therefore holds promise for identif...
53 CitationsSource
#1Craig S. Anderson (RPA: Royal Prince Alfred Hospital)H-Index: 80
#2Yining Huang (PKU: Peking University)H-Index: 18
Last. John Chalmers (RPA: Royal Prince Alfred Hospital)H-Index: 85
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Summary Background There is much uncertainty about the effects of early lowering of elevated blood pressure (BP) after acute intracerebral haemorrhage (ICH). Our aim was to assess the safety and efficiency of this treatment, as a run-in phase to a larger trial. Methods Patients who had acute spontaneous ICH diagnosed by CT within 6 h of onset, elevated systolic BP (150–220 mm Hg), and no definite indication or contraindication to treatment were randomly assigned to early intensive lowering of BP...
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#2Craig S. AndersonH-Index: 80
Last. Konrad JamrozikH-Index: 68
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Background and Purpose— We studied temporal trends in major stroke outcomes in Perth, Western Australia (WA), comparing 3 12-month periods, roughly 5 years apart, between 1989 and 2001. Methods— The Perth Community Stroke Study (PCSS) used uniform definitions and procedures in a representative segment (approximately 143 000 people in the year 2000) of Perth, WA. Crude and age-standardized incidence and 28-day case fatality for stroke in the different study periods were compared using Poisson reg...
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#1Caroline E. Lovelock (University of Oxford)H-Index: 9
#2Andy Molyneux (University of Oxford)H-Index: 15
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Summary Background UK stroke mortality data suggest that the incidence of haemorrhagic stroke has fallen in the past 20 years, but these data do not include deaths of individuals aged 75 years or over. Trends in the older population might differ, since cause varies with age. Our aim was to investigate changes in the population-based incidence of intracerebral haemorrhage according to age and likely aetiology. Methods We used data from the Oxford Community Stroke Project (OCSP; 1981–86) and the O...
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#1Daniel L. Labovitz (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 15
#2A. Halim (UVM: University of Vermont)H-Index: 3
Last. Ralph L. Sacco (Columbia University)H-Index: 126
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Background: Black and Hispanic Americans have a greater risk of primary intracerebral hemorrhage (ICH) than whites. Deep ICH is most often associated with hypertension, while lobar ICH is associated with cerebral amyloid angiopathy. The authors conducted a population-based incidence study to directly compare the incidence of deep vs lobar ICH in all three race-ethnic groups. Methods: The authors used an active hospital and community surveillance program and autopsy reports to identify incident I...
149 CitationsSource
#1Peter M. Rothwell (University of Oxford)H-Index: 108
#2A J Coull (University of Oxford)H-Index: 3
Last. P AnslowH-Index: 6
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Summary Background The incidence of stroke is predicted to rise because of the rapidly ageing population. However, over the past two decades, findings of randomised trials have identified several interventions that are effective in prevention of stroke. Reliable data on time-trends in stroke incidence, major risk factors, and use of preventive treatments in an ageing population are required to ascertain whether implementation of preventive strategies can offset the predicted rise in stroke incid...
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#2Naoyoshi Takatsuka (Gidai: Gifu University)H-Index: 25
Last. Hiroyuki Shimizu (Gidai: Gifu University)H-Index: 49
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Background and Purpose— Despite the evidence for a positive association of dietary salt and blood pressure, the few prospective studies that have assessed the association between dietary salt and stroke have reported inconsistent results. The purpose of this study was to examine the relation between sodium intake and death from stroke in a population-based cohort of Japanese men and women. Methods— In 1992, usual diet including sodium intake was determined in 13 355 men and 15 724 women in Takay...
216 CitationsSource
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#2Ailing Liu (HAU: Hunan Agricultural University)H-Index: 1
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Abstract(−)-Epicatechin (EC) is a flavanol easily obtained through the diet and is present in tea, cocoa, vegetables, fruits, and cereals. Recent studies have shown that EC protects human health an...
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#2Honglei Ren (Johns Hopkins University)H-Index: 1
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Intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity. However, we have few options for ICH therapy and limited knowledge about post-ICH neuronal death and related mechanisms. In the aftermath of ICH, iron overload within the perihaematomal region can induce lethal reactive oxygen species (ROS) production and lipid peroxidation, which contribute to secondary brain injury. Indeed, iron chelation therapy has shown efficacy in preclinical ICH studies. Rec...
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Abstract Perturbations in iron homeostasis and iron accumulation feature in several neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). Proteins such as α-synuclein, tau and amyloid precursor protein that are pathologically associated with neurodegeneration are involved in molecular crosstalk with iron homeostatic proteins. Quantitative susceptibility mapping, an MRI based non-invasive technique, offers proximal evalua...
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#2Lan-Jun Li (Zhengzhou University)H-Index: 1
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Intracerebral hemorrhage (ICH) is a fatal acute cerebrovascular disease, with a high morbidity and mortality. Following ICH, erythrocytes release heme and several of its metabolites, thereby contributing to brain edema and secondary brain damage. Heme oxygenase is the initial and rate-limiting enzyme of heme catabolism, and the expression of heme oxygenase-1 (HO-1) is rapidly induced following acute brain injury. As HO-1 exerts it effects via various metabolites, its role during ICH remains comp...
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Background: Chinese populations have a higher stroke incidence, a higher proportion of intracerebral hemorrhage (ICH), and a lower proportion of ischemic stroke (
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Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity. When a diseased artery within the brain bursts, expansion and absorption of the resulting hematoma trigger a series of reactions that cause primary and secondary brain injury. Microglia are extremely important for removing the hematoma and clearing debris, but they are also a source of ongoing inflammation. This article discusses the role of microglial activation/polarization and related inflammatory mediato...
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ABSTRACTObjective: Hyperbaric oxygen (HBO) is widely used in treating various neurological diseases. However, HBO for treatment of intracerebral haemorrhage (ICH) remains controversial, in either animal or clinical studies. Therefore, we conducted this systematic review and meta-analysis on studies describing the efficacy of HBO in animal models of ICH.Methods: Studies were identified by searching mainstream databases through November 2015. The efficacy of HBO in animal models of ICH was assesse...
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IntroductionThe purpose was to explore if there are differences in extent of change in upper extremity motor function and activity capacity, in persons with ischaemic versus haemorrhagic stroke, during the first year post stroke.Patients and methodsOne hundred seventeen persons with stroke (ischaemic n = 98, haemorrhagic n = 19) and reduced upper extremity function 3 days after onset were consecutively included to the Stroke Arm Longitudinal Study at the University of Gothenburg (SALGOT) from a ...
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#1Mathieu SchertzH-Index: 2
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Background Incidence of spontaneous subarachnoid hemorrhages (SAH) varies wildly across the world and seems to be low in Central and South America (4.2 per 100 000 person-years; CI 95%; 3.1–5.7). The objective of our study was to describe the characteristics of SAH and to estimate its incidence and severity in Martinique, a small French island located in the Caribbean Sea. Methods Due to its insular nature and small captive population, Martinique is ideal for the setting up of population-based e...
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