Structurally related cytotoxic effects of flavonoids on human cancer cells in vitro

Flavonoids exist extensively in the human diet, and a variety of health effects have been ascribed to them. The cytotoxic effects of 23 flavonoids on breast cancer cells (MDA-MB-231 and MCF-7), colorectal carcinoma cells (LoVo and DLD-1) and prostatic cancer cells (PC3) were investigated. By comparing the cytotoxicity (EC50) of selected molecules that differ in only one structure element, we identified several structural properties associated...