TET proteins and 5‐methylcytosine oxidation in hematological cancers
Abstract
DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, and X-chromosome inactivation. Cancer cells display highly dysregulated DNA methylation profiles characterized by global hypomethylation in conjunction with hypermethylation of promoter CpG islands that presumably lead to genome instability and aberrant expression of tumor suppressor genes or oncogenes. The recent discovery of...
Paper Details
Title
Published Date
Dec 15, 2014
Journal
Volume
263
Issue
1
Pages
6 - 21
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