Cancer Genome Landscapes
Abstract
Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer. For most cancer types, this landscape consists of a small number of "mountains" (genes altered in a high percentage of tumors) and a much larger number of "hills" (genes altered infrequently). To date, these studies have revealed ~140 genes that, when altered by intragenic mutations, can promote or "drive" tumorigenesis. A...
Paper Details
Title
Cancer Genome Landscapes
Published Date
Mar 28, 2013
Journal
Volume
339
Issue
6127
Pages
1546 - 1558
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