Clonal allelic predetermination of immunoglobulin-κ rearrangement
Abstract
Although most genes are expressed biallelically, a number of key genomic sites--including immune and olfactory receptor regions--are controlled monoallelically in a stochastic manner, with some cells expressing the maternal allele and others the paternal allele in the target tissue. Very little is known about how this phenomenon is regulated and programmed during development. Here, using mouse immunoglobulin-κ (Igκ) as a model system, we...
Paper Details
Title
Clonal allelic predetermination of immunoglobulin-κ rearrangement
Published Date
Sep 30, 2012
Journal
Volume
490
Issue
7421
Pages
561 - 565
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