Steric Aspects of the Binding of Monofunctional Platinum(II) Complexes to Sites on Nucleobases: Metal Complex “Flatness” as a Structural Element of Speciation

Through the use of an established repulsive energy methodology, the endocyclic nitrogens of the common nucleobases have been probed by monofunctional PtII(A)3 moieties, where A ≡ NH3 and (A)3 ≡ diethylenetriamine (dien) and N1,N1,N4,N7,N7-pentamethyldiene (pmdien). These three complexes have been selected to represent, respectively, a gradual buildup of bulk on either side of the coordination plane. The values of the resulting steric parameters,...