Match!

PEGylation of Porous Silicon Using Click Chemistry

Published on Aug 1, 2008in Langmuir3.683
· DOI :10.1021/la801619v
Leanne Britcher12
Estimated H-index: 12
,
Timothy J. Barnes20
Estimated H-index: 20
+ 1 AuthorsClive A. Prestidge39
Estimated H-index: 39
Abstract
Porous silicon has received considerable interest in recent years in a range of biomedical applications, with its performance determined by surface chemistry. In this work, we investigate the PEGylation of porous silicon wafers using click chemistry. The porous silicon wafer surface chemistry was monitored at each stage of the reaction via photoacoustic Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, whereas sessile drop contact angle and model protein adsorption measurements were used to characterize the final PEGylated surface. This work highlights the simplicity of click-chemistry-based functionalization in tailoring the porous silicon surface chemistry and controlling protein−porous silicon interactions.
  • References (0)
  • Citations (35)
📖 Papers frequently viewed together
20073.68Langmuir
190 Citations
8,338 Citations
20083.68Langmuir
81 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References0
Newest
Cited By35
Newest
Abstract The natural biodegradabilty of porous silicon (pSi) in physiological media limits its wider usage for implantable systems. We report the stabilization of porous silicon (pSi) membranes by chemical surface oxidation using RCA1 and RCA2 protocols, which was followed by a PEGylation process using a silane-PEG. These surface modifications stabilized the pSi to allow a long period of immersion in PBS, while leaving the pSi surface sufficiently hydrophilic for good filtration and diffusion of...
1 CitationsSource
#1Feng WangH-Index: 2
#2Timothy J. BarnesH-Index: 20
Last. Clive A. PrestidgeH-Index: 39
view all 3 authors...
Porous silicon (pSi) continues to receive considerable interest for use in applications ranging from sensors, biological scaffolds, therapeutic delivery systems to theranostics. Critical to all of these applications is pSi degradation and stabilization in biological media. Here we report on progress towards the development of a mechanistic understanding for the dissolution behavior of native (unoxidized) and thermally oxidized (200–600 °C) pSi microparticles. Fourier transform infrared (FTIR) sp...
Source
#1Yuan Chen (RU: Rutgers University)H-Index: 8
#2Hao Fan (RU: Rutgers University)H-Index: 3
Last. Elena Galoppini (RU: Rutgers University)H-Index: 31
view all 3 authors...
Source
#1Gurjaspreet Singh (Panjab University, Chandigarh)H-Index: 12
#2Jasbhinder Singh (LPU: Lovely Professional University)H-Index: 1
Last. Sanjay Chhibber (Panjab University, Chandigarh)H-Index: 25
view all 7 authors...
Abstract A single step Cu (I) assisted click silylation reaction had been used for the synthesis of novel Schiff based 1,2,3-triazole bridged silatrane (SBTBS)-scaffolds ( 5a-5f ) using polyfunctionalised Schiff based 1,2,3-triazole bridged organotriethoxysilanes (SBTBOTS) ( 4a-4f ) as precursors. These compounds were synthesized in excellent yields using an economical, simple and biocompatible synthetic procedure and their structures were characterized by various spectroscopy methods such as IR...
3 CitationsSource
Alcohol-based monolayers were successfully formed on the surfaces of silicon oxides through reactions performed in polar aprotic solvents. Monolayers prepared from alcohol-based reagents have been previously introduced as an alternative approach to covalently modify the surfaces of silicon oxides. These reagents are readily available, widely distributed, and are minimally susceptible to side reactions with ambient moisture. A limitation of using alcohol-based compounds is that previous reactions...
1 CitationsSource
#1Yoshinori Yamanoi (UTokyo: University of Tokyo)H-Index: 18
#2Mariko Miyachi (UTokyo: University of Tokyo)H-Index: 10
Last. Toshiaki Suhara (UTokyo: University of Tokyo)H-Index: 55
view all 3 authors...
This chapter summarizes research progress in the immobilization of metal nanoparticles, nanosized organic and complex molecules, and biological molecules on electrode surfaces with an emphasis on our recent study. Self-assembled monolayers (SAMs) are an excellent model system to study the binding of molecular-sized objects on surfaces. They are a simple, effective, and highly versatile method for modifying various surfaces with different nanosized molecules at the molecular level with precise co...
1 CitationsSource
#1Jasper C. Small (Wabash College)H-Index: 1
#2Hieu Minh Dam (Wabash College)H-Index: 1
Last. Lon A. Porter (Wabash College)H-Index: 1
view all 8 authors...
Abstract Porous silicon (PSi), with its large surface area-to-volume ratio and tunable surface morphology, remains an attractive substrate for applications ranging from optoelectronics to medical diagnostics. However, one significant obstacle facing the development of specialized PSi devices is the inherent instability of its native, silicon-hydride surface termination. In order to bypass this difficulty, a number of benchtop hydrosilylation reactions have been reported for functionalizing organ...
3 CitationsSource
#1Ghodsi Mohammadi Ziarani (Alzahra University)H-Index: 26
#2Zahra Hassanzadeh (Alzahra University)H-Index: 1
Last. Alireza Badiei (UT: University of Tehran)H-Index: 34
view all 5 authors...
Click chemistry is undoubtedly the most powerful 1,3-dipolar cycloaddition reaction in organic synthesis. Because the click reaction can be used to straightforwardly attach two different molecules, this type of synthesis has attracted much attention from scientists. If the desired molecule is functionalized with azide or alkyne group(s), it can be readily attached to the target molecule or substrate through the click reaction. The potential of this reaction is very great; moreover, alkyne and az...
16 CitationsSource
#1Qian Yu (Soochow University (Suzhou))H-Index: 23
#2Linnea K. Ista (UNM: University of New Mexico)H-Index: 26
Last. Gabriel P. LopezH-Index: 55
view all 5 authors...
Surfaces with end-grafted, nanopatterned polymer brushes that exhibit well-defined feature dimensions and controlled chemical and physical properties provide versatile platforms not only for investigation of nanoscale phenomena at biointerfaces, but also for the development of advanced devices relevant to biotechnology and electronics applications. In this review, we first give a brief introduction of scaling behavior of nanopatterned polymer brushes and then summarize recent progress in fabrica...
23 CitationsSource
#1Hongkun He (CMU: Carnegie Mellon University)H-Index: 18
#2Saadyah Averick (CMU: Carnegie Mellon University)H-Index: 21
Last. KrzysztofMatyjaszewski (CMU: Carnegie Mellon University)H-Index: 139
view all 6 authors...
Covalent attachment of poly(ionic liquid)s (PILs) by click chemistry on glass or silicon (Si) surfaces was performed. Poly[1-(4-vinylbenzyl)-3-butylimidazolium bis(trifluoromethylsulfonyl)imide] (polyVBBI+Tf2N−), and copolymers of polyVBBI+Tf2N− with fluorescein O-methacrylate were synthesized by conducting an atom transfer radical polymerization (ATRP) from initiators containing azide or thioacetate groups. The azide- and thiol-terminated PILs were then successfully grafted onto alkyne and alke...
25 CitationsSource