Mitochondrial DNA damage and repair during ischemia–reperfusion injury of the heart
Abstract
Ischemia-reperfusion (IR) injury of the heart generates reactive oxygen species that oxidize macromolecules including mitochondrial DNA (mtDNA). The 8-oxoguanine DNA glycosylase (OGG1) works synergistically with MutY DNA glycosylase (MYH) to maintain mtDNA integrity. Our objective was to study the functional outcome of lacking the repair enzymes OGG1 and MYH after myocardial IR and we hypothesized that OGG1 and MYH are important enzymes to...
Paper Details
Title
Mitochondrial DNA damage and repair during ischemia–reperfusion injury of the heart
Published Date
Jan 1, 2015
Volume
78
Pages
9 - 22
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