Aldose reductase in the polyol pathway: A potential target for the therapeutic intervention of diabetic complications.
Abstract
Aldose reductase (AR), an enzyme in the polyol pathway, catalyzes the reduction of glucose to sorbitol. Sorbitol is subsequently converted to fructose by sorbitol dehydrogenase. The two enzymes constitute the sorbitol (polyol) pathway, the alternate route of glucose metabolism. The acceleration of this pathway and ensuing metabolic imbalances have been postulated to play a key role in the pathogenesis of diabetic complications. Using a...
Paper Details
Title
Aldose reductase in the polyol pathway: A potential target for the therapeutic intervention of diabetic complications.
Published Date
Jan 1, 1998
Volume
111
Issue
3
Pages
137 - 145
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