Selective phosphorylation modulates the PIP2 sensitivity of the CaM–SK channel complex
Abstract
Phosphatidylinositol bisphosphate (PIP2) regulates the activities of many membrane proteins, including ion channels, through direct interactions. However, the affinity of PIP2 is so high for some channel proteins that its physiological role as a modulator has been questioned. Here we show that PIP2 is a key cofactor for activation of small conductance Ca2+-activated potassium channels (SKs) by Ca(2+)-bound calmodulin (CaM). Removal of the...
Paper Details
Title
Selective phosphorylation modulates the PIP2 sensitivity of the CaM–SK channel complex
Published Date
Aug 10, 2014
Journal
Volume
10
Issue
9
Pages
753 - 759
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