Neonatal tactile stimulation changes anxiety-like behavior and improves responsiveness of rats to diazepam
Abstract
In this study we evaluated the influence of neonatal tactile stimulation (TS) on behavioral and biochemical effects related to a low dose of diazepam (DZP) in adult rats. Male pups of Wistar rats were handled (TS) daily from PND1 to PND21 for 10 min, while unhandled (UH) rats were not touched. In adulthood, half the animals of each group received a single administration of diazepam (0.25mg/kg body weight i.p.) or vehicle and then were submitted...
Paper Details
Title
Neonatal tactile stimulation changes anxiety-like behavior and improves responsiveness of rats to diazepam
Published Date
Sep 1, 2012
Journal
Volume
1474
Pages
50 - 59
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