Citrate enhances the protective effect of orally administered bismuth subnitrate against the nephrotoxicity of cis -diamminedichloroplatinum
Abstract
Attenuation of the renal toxicity of cis-diamminedichloroplatinum (CDDP) is important in the use of this effective but cytotoxic anticancer agent. We have previously shown that the renal toxicity of CDDP can be efficiently reduced by the induction of metallothionein (MT) by preadministration of bismuth compounds in mice. Bismuth subnitrate (BSN) is used as an antigastric ulcer agent and as an antidiarrheic agent, and is suitable for inducing MT...
Paper Details
Title
Citrate enhances the protective effect of orally administered bismuth subnitrate against the nephrotoxicity of cis -diamminedichloroplatinum
Published Date
Jan 1, 2004
Volume
53
Issue
1
Pages
33 - 38
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