Deletion of aquaporin‐4 changes the perivascular glial protein scaffold without disrupting the brain endothelial barrier

Expression of the water channel aquaporin‐4 (AQP4) at the blood–brain interface is dependent upon the dystrophin associated protein complex. Here we investigated whether deletion of the Aqp4 gene affects the molecular composition of this protein scaffold and the integrity of the blood–brain barrier. High‐resolution immunogold cytochemistry revealed that perivascular expression of α‐syntrophin was reduced by 60% in Aqp4 −/− mice. Additionally,...