Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
Abstract
A longevity gene, sirtuin 1 (SIRT1), can attenuate age-dependent induction of left ventricular dysfunction. This study aimed to characterize the role of SIRT1 in the tolerance of aged heart to ischemic insults. Male C57BL/6 young (4-6 mo) and aged (24-26 mo) mice were used to determine the role of SIRT1 in myocardial ischemia/reperfusion (I/R) tolerance. SIRT1 localization was assessed by confocal microscopy. Immunoblotting was used to evaluate...
Paper Details
Title
Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
Published Date
Nov 1, 2013
Journal
Volume
27
Issue
11
Pages
4332 - 4342
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