Treatment of Peyronie's disease with PDE5 inhibitors: an antifibrotic strategy

Pharmacological treatments for Peyronie's disease generally have limited success. Research using cell culture systems and animal models has provided insights into the fibrotic mechanisms underlying this disease, and has revealed a novel and potentially effective application of phosphodiesterase 5 inhibitors in this context. Peyronie's disease (PD) is a localized fibrotic condition of the tunica albuginea that is associated with risk factors for...