Membrane-Induced Structural Rearrangement and Identification of a Novel Membrane Anchor in Talin F2F3
Abstract
Experimental challenges associated with characterization of the membrane-bound form of talin have prevented us from understanding the molecular mechanism of its membrane-dependent integrin activation. Here, utilizing what we believe to be a novel membrane mimetic model, we present a reproducible model of membrane-bound talin observed across multiple independent simulations. We characterize both local and global membrane-induced structural...
Paper Details
Title
Membrane-Induced Structural Rearrangement and Identification of a Novel Membrane Anchor in Talin F2F3
Published Date
Nov 1, 2014
Journal
Volume
107
Issue
9
Pages
2059 - 2069
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