Mitochondrial tumour suppressors: a genetic and biochemical update
Abstract
Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins (SDHB, SDHC and fumarate hydratase) have been implicated in tumour susceptibility. Mutations in these proteins are principally involved in familial predisposition to benign tumours, but the spectrum of inherited lesions is increasingly recognized to include malignant tumours,...
Paper Details
Title
Mitochondrial tumour suppressors: a genetic and biochemical update
Published Date
Nov 1, 2005
Journal
Volume
5
Issue
11
Pages
857 - 866
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Notes
History