Promyelocytic Leukemia Protein in Retinoic Acid-Induced Chromatin Remodeling of Oct4 Gene Promoter

Volume: 29, Issue: 4, Pages: 660 - 669
Published: Apr 1, 2011
Abstract
Promyelocytic leukemia (Pml) protein is required for Oct4 gene expression and the maintenance of its open chromatin conformation in stem cells. In proliferating stem cells, Pml-nuclear body, along with transcription factors TR2, steroidogenic factor 1 (SF1) and Sp1, and Brg1-dependent chromatin remodeling complex (BRGC), associates with conserved region 1 (CR1) of this promoter to maintain a nucleosome-free region for gene activity. Retinoic...
Paper Details
Title
Promyelocytic Leukemia Protein in Retinoic Acid-Induced Chromatin Remodeling of Oct4 Gene Promoter
Published Date
Apr 1, 2011
Journal
Volume
29
Issue
4
Pages
660 - 669
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