Nickel Block of Three Cloned T-Type Calcium Channels: Low Concentrations Selectively Block α1H
Abstract
Nickel has been proposed to be a selective blocker of low-voltage-activated, T-type calcium channels. However, studies on cloned high-voltage-activated Ca(2+) channels indicated that some subtypes, such as alpha1E, are also blocked by low micromolar concentrations of NiCl(2). There are considerable differences in the sensitivity to Ni(2+) among native T-type currents, leading to the hypothesis that there may be more than one T-type channel. We...
Paper Details
Title
Nickel Block of Three Cloned T-Type Calcium Channels: Low Concentrations Selectively Block α1H
Published Date
Dec 1, 1999
Journal
Volume
77
Issue
6
Pages
3034 - 3042
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