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Effect of femoral nerve resection on progression of cartilage degeneration induced by anterior cruciate ligament transection in rabbits

Published on Dec 1, 2002in Journal of Orthopaedic Science1.257
· DOI :10.1007/s007760200119
Daisuke Hanashi2
Estimated H-index: 2
(YCU: Yokohama City University),
Tomihisa Koshino29
Estimated H-index: 29
(YCU: Yokohama City University)
+ 1 AuthorsTomoyuki Saito37
Estimated H-index: 37
(YCU: Yokohama City University)
Abstract
The purpose of this study was to evaluate the effect of femoral nerve resection on the progression of cartilage degeneration in an anterior cruciate ligament transection (ACLT) and partial meniscectomy (PM) model in rabbits. To induce degeneration of articular cartilage, PM and ACLT were performed on the bilateral knees of 24 rabbits, and femoral sensory nerve selective resection (FNR) was additionally performed on the left knee. Six rabbits each were killed 6 and 10 weeks after surgery to observe early cartilage degeneration and 17 and 24 weeks after surgery to evaluate the late phase. Mankin's histological score at 10 weeks (7.5 ± 2.7 points; mean ± SD) after surgery in the FNR group was higher than that at 6 weeks (3.0 ± 0.6 points) (P < 0.05). In the control group the score at 17 weeks (7.8 ± 2.0 points) was higher than that at 6 weeks (2.7 ± 0.5 points) (P < 0.05). The concentration of chondroitin sulfate in the joint fluid was quantified by high-performance liquid chromatography. The concentration of chondroitin 6-sulfate in the FNR group at 10 weeks (11.6 ± 4.1 nmol/ml) was higher than that at the other times and that of the control group at 10 weeks (5.4 ± 3.2 nmol/ml) after surgery (P < 0.05). These results indicate that FNR may promote the progression of cartilage degeneration in knees with PM and ACLT.
  • References (24)
  • Citations (6)
References24
Newest
Synovial tissue was obtained from medial, lateral, and suprapatellar sites of 21 knees (15 patients) with medial compartmental osteoarthritis at surgery. All patients reported pain around the medial joint of their knees while walking and climbing stairs. For investigation of the synovial innervation
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#1Harumoto Yamada (National Defense Medical College)H-Index: 10
#2Satoshi MiyauchiH-Index: 3
Last. Kyosuke Fujikawa (National Defense Medical College)H-Index: 24
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Abstract We determined the levels of chondroitin sulfate (CS) isomers in the synovial fluid of patients with hip osteoarthritis (OA) to investigate their significance as markers reflecting extracellular matrix metabolism in joint tissues. A cross-sectional study of synovial fluid aspirated from 50 hip joints of 50 patients with OA was performed. Concentrations of chondroitin-4-sulfate (C4S) and chondroitin-6-sulfate (C6S) were determined by high-performance liquid chroma-tography. Levels of each...
21 CitationsSource
OBJECTIVES--The exact regulation of the synthesis of cartilage specific molecules, such as collagen type II and aggrecan, by articular chondrocytes is unknown, but growth factors and hormones probably play an important part. The effects of glucocorticosteroids (prednisolone and triamcinolone), in combination with insulin-like growth factor I (IGF-I), on the synthesis and hydrodynamic volume of proteoglycans from murine patellar cartilage were investigated. METHODS--The in vitro effect of IGF-I a...
28 CitationsSource
: Degenerative findings observed in the articular cartilage of the knee during high tibial osteotomy with arthrotomy, unicompartmental arthroplasty, or total replacement were classified into 9 grades: Grade 0--normal, Grade I--yellow discoloration, Grade II--softening and unevenness, Grade III--fasciculation and attrition, Grade IV-a--erosion, Grade IV-b--ulcer down to subchondral bone, Grade IV-c--eburnation of subchondral bone, Grade V-a--bone destruction in an area less than 5 mm in depth, an...
29 Citations
#1Masayuki Shinmei (National Defense Medical College)H-Index: 14
#2Satoshi Miyauchi (National Defense Medical College)H-Index: 1
Last. Kyosuke Miyazaki (National Defense Medical College)H-Index: 8
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Objective. To investigate the correlation between joint disease and the composition of chondroitin sulfate in the joint fluid, unsaturated disaccharide isomers of chondroitin 4—sulfate (Δdi-4S) and chondroitin 6—sulfate (Δdi-6S) were measured in joint fluids obtained from patients with osteoarthritis (OA), rheumatoid arthritis (RA), or traumatic arthritis (TA). Methods. These pathologic joint fluids were digested with chondroitinase ABC, and the Δdi-4S and Δdi-6S produced were determined by high...
136 CitationsSource
#1Brian L. O'Connor (IU: Indiana University)H-Index: 19
#2D. M. Visco (IU: Indiana University)H-Index: 6
Last. L A Kalasinski (IU: Indiana University)H-Index: 1
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The development of osteoarthrosis in unstable knee joints of dogs after transection of the anterior cruciate ligament is greatly accelerated when the afferent nerve fibers from the ipsilateral hindlimb have been interrupted by dorsal root ganglionectomy before transection. The purpose of the current study was to determine whether partial loss of the afferent fibers from the knee joints of dogs, accomplished by neurectomy of the primary articular nerves before transection of the ligament, also ac...
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A meniscal prosthesis made of Dacron with polyure thane coating was tested as a substitute for the medial meniscus in a rabbit experimental model concentrating on biomechanical behavior of the knee joint and gross and histologic evaluation 3 months after surgery. The results were compared to sham-operated knees, knees with a peripheral incision of the medial meniscus, and knees with a total meniscectomy. Knees with prosthe sis implantation had the same stiffness as knees with sham-operation or m...
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The pathophysiology of acute joint inflammation remains unclear. Evidence is available to suggest a neurally mediated component to the inflammatory process. Acute joint inflammation in the rat knee, induced by intra-articular injection of 2% carrageenan, was reduced by 44% in animals whose knee had previously been injected with 1% capsaicin, while chronic joint denervation produced a 37% reduction. These results indicate a significant neurogenic component in this model of acute joint inflammatio...
105 CitationsSource
#1Hidenao Toyoda (Chiba University)H-Index: 28
#2Kazufusa Shinomiya (Chiba University)H-Index: 17
Last. Toshio Imanari (Chiba University)H-Index: 26
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A highly sensitive high performance liquid chromatographic method with fluorometric postcolumn labeling using 2-cyanoacetamide was developed for determination of unsaturated disaccharides produced enzymatically from chondroitin sulfates (ChS). The calibration curves of the unsaturated disaccharides were linear over the range from 2pmol to 5nmol. This method was applied to the analysis of normal rabbit plasma for ChS to verify the sensitivity and practicality.
57 CitationsSource
#1Paulo A.S. Mourão (UFRJ: Federal University of Rio de Janeiro)H-Index: 46
The relative concentrations of chondroitin 4– and chondroitin 6–sulfate in different normal human cartilages are reported. Articular cartilages contained higher concentrations of chondroitin 6-sulfate, whereas growth cartilages contained nearly equal amounts of chondroitin 4– and chondroitin 6–sulfate. Adult cartilages, in which the calcification process is already complete, contained only chondroitin 6–sulfate. The results suggest that chondroitin 6–sulfate is related to the integrity of the ar...
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In this study, we aimed to determine the synergistic effects of a formula consisting of dried pomegranate concentrate powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 (g/g) (PCP:EC:AR) in a surgically induced osteoarthritis (OA) rabbit model. PCP:EC:AR was orally administered once per day. Knee thickness, maximum extension of the knee joint, gross articular defect area, and the histopathological appearance of the cartilage were monitored, along with serum collagen type II C-telopeptide (CTX...
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Methodological differences between in vitro and in vivo studies on cartilage overloading complicate the comparison of outcomes. The rationale of the current review was to (i) identify consistencies and inconsistencies between in vitro and in vivo studies on mechanically-induced structural damage in articular cartilage, such that variables worth interesting to further explore using either one of these approaches can be identified; and (ii) suggest how the methodologies of both approaches may be a...
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#1Gregor Reisig (Heidelberg University)H-Index: 4
#2Michael Kreinest (Heidelberg University)H-Index: 7
Last. Markus Schwarz (Heidelberg University)H-Index: 13
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Introduction The Gottingen Minipig (GM) is used as large animal model in articular cartilage research. The aim of the study was to introduce osteoarthritis (OA) in the GM by resecting the anterior cruciate ligament (ACLR) according to Pond and Nuki, verified by histological and magnetic resonance imaging (MRI) scoring as well as analysis of gene and protein expression. Materials and Methods The eight included skeletally mature female GM were assessed after ACLR in the left and a sham operation i...
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#1Daniel L. Miranda (Wyss Institute for Biologically Inspired Engineering)H-Index: 9
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Abstract Prolonged immobilization in hospitalized children can lead to fragility fractures and muscle contractures and atrophy. The purpose of this study was to develop a lower-extremity disuse rabbit model with musculoskeletal changes similar to those observed in children subjected to prolonged immobilization. Six-week-old rabbits were randomly assigned to control (CTRL, n =4) or bilateral sciatic and femoral neurectomy (bSFN, n =4) groups. Trans-axial helical CT scans of each rabbit׳s hind lim...
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#1P. Wu (SYSU: Sun Yat-sen University)H-Index: 1
#2Nilsson Holguin (WashU: Washington University in St. Louis)H-Index: 12
Last. Linda J. Sandell (WashU: Washington University in St. Louis)H-Index: 45
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Objective Joint trauma can lead to a spectrum of acute lesions, including cartilage degradation, ligament or meniscus tears, and synovitis, all potentially associated with osteoarthritis (OA). This study was undertaken to generate and validate a murine model of knee joint trauma following noninvasive controlled injurious compression in vivo. Methods The right knees of 8-week-old mice were placed in a hyperflexed position and subjected to compressive joint loading at 1 of 3 peak forces (3N, 6N, o...
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#1Sheila Laverty (UdeM: Université de Montréal)H-Index: 31
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Summary Aim The primary goal of this body of work is to suggest a standardized system for histopathological assessment of experimental surgical instability models of osteoarthritis (OA) in rabbits, building on past experience, to achieve comparability of studies from different centres. An additional objective is to review methodologies that have been employed in the past for assessing OA in rabbits with particular reference to the surgical anterior cruciate ligament transection (ACLT) model. Met...
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