Effect of acute in vivo sildenafil citrate and in vitro 8-bromo-cGMP treatments on semen parameters and sperm function

ObjectiveTo determine the effect of acute in vivo sildenafil citrate (VIAGRA) and in vitro 8-Bromo-cGMP treatments on semen parameters and sperm function.DesignProspective double-blind, placebo-controlled, crossover, two-period clinical investigation.SettingHealthy volunteers in an academic research environment.Patient(s)Twenty male volunteers with normal erectile function and normal electrocardiogram were recruited.Intervention(s)In vivo: 50 mg...