Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity
Volume: 449, Issue: 1-2, Pages: 47 - 56
Published: May 1, 2006
Abstract
MAPK-activated protein kinase-2 (MAPKAPK2) regulates the synthesis of tumor necrosis factor and other cytokines and is a potential drug target for inflammatory diseases. Five protein constructs were produced in 4-10mg quantities per liter of culture media using baculovirus-infected insect cells and characterized for kinase activity, thermal stability, and ligand-binding affinity. Compared to construct 1-370, removal of the C-terminal...
Paper Details
Title
Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity
Published Date
May 1, 2006
Volume
449
Issue
1-2
Pages
47 - 56
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