After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult.

Volume: 49, Issue: 5, Pages: 738 - 747
Published: Sep 1, 2010
Abstract
null null In this work we describe the protective effects of quercetin against H 2 O 2 null in 24-h-pretreated neuronal cultures. We explored quercetin availability and subcellular fate through the use of HPLC-Diode Array Detection (DAD), epifluorescence, and confocal microscopy. We focused on quercetin modulation of thiol-redox systems by evaluating changes in mitochondrial thioredoxin Trx2, the levels of total glutathione (GSH), and the...
Paper Details
Title
After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult.
Published Date
Sep 1, 2010
Volume
49
Issue
5
Pages
738 - 747
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