"Double depression": two-year follow-up.

Published on Jun 1, 1983in American Journal of Psychiatry 13.40
· DOI :10.1176/ajp.140.6.689
Martin B. Keller113
Estimated H-index: 113
Phillip Lavori6
Estimated H-index: 6
+ 2 AuthorsGerald L. Klerman73
Estimated H-index: 73
Of 3 1 6 patients with a major depressive disorder who were followed for between 6 months and 2 years, 80 (25%) had a preexisting chronic minor depression of at least 2 years’ duration. The chronic minor depression reduced the apparent effect of the known predictors of recovery and relapse from the major depressive disorder and predicted a very pernicious course for the chronic depression. Furthermore, the longer the patient continued to suffer from a chronic minor depression after recovering from the major depression, the greater the probability that relapse into another major depression would preempt recovery from the chronic depression. (Am J Psychiatry 140:689-694, 1983)
  • References (12)
  • Citations (200)
Published on Apr 1, 1982in American Journal of Psychiatry 13.40
Martin B. Keller113
Estimated H-index: 113
Robert W. Shapiro13
Estimated H-index: 13
Although ‘ ‘double depression ‘ ‘-major depressive disorder superimposed on an underlying chronic depression-is a f requent phenomenon, the concept has not been well formulated clinically and has rarely been described in the research literature. The authors found that 1) 26% of 101 patients who met the criteria for major depressive disorder had an underlying chronic depressive disorder of at least 2 years’ duration, 2) “recovery” ratesfor patients with superimposed depression differed greatly de...
275 Citations Source Cite
Published on Jan 1, 1981in Archives of General Psychiatry
Jean Endicott94
Estimated H-index: 94
Jacob Cohen58
Estimated H-index: 58
+ 2 AuthorsStavros Sarantakos5
Estimated H-index: 5
• Investigators who wish to use new procedures usually wish to relate their results to those already in the literature. This often results in the use of both old and new measures. The Schedule for Affective Disorders and Schizophrenia Regular and Change Versions (SADS and SADS-C) have advantages over the widely used Hamilton Depression Rating Scale (HDRS). A procedure was developed to extract the HDRS score from the SADS and SADS-C. The comparative reliability and the validity of the extracted H...
335 Citations Source Cite
Published on Jul 1, 1979in Archives of General Psychiatry
Martin M. Katz18
Estimated H-index: 18
(National Institutes of Health),
Steven Secunda5
Estimated H-index: 5
(National Institutes of Health)
+ 1 AuthorsStephen H. Koslow33
Estimated H-index: 33
(National Institutes of Health)
• This is a report on the history and implications of the collaborative effort that evolved from the 1969 National Institute of Mental Health conference on the psychobiology of depression. The major issues identified at that time were the need to (1) assess relative validities of current systems of nosology and (2) retest critical biological hypotheses concerning the etiology and nature of the depressive disorders. Research was required that would be multidisciplinary and involve clinical settin...
191 Citations Source Cite
Published on Nov 1, 1982in Archives of General Psychiatry
Janet B. W. Williams69
Estimated H-index: 69
Robert L. Spitzer82
Estimated H-index: 82
• For several years the Research Diagnostic Criteria (RDC) have been used widely by investigators to select and describe research subjects. These criteria were used as the initial basis for the specified diagnostic criteria for the major diagnostic categories of DSM-III . With the availability of DSM-III in early 1980, research investigators involved in ongoing studies using the RDC and those planning future studies need to understand the relationship between these two systems so that they can m...
85 Citations Source Cite
Published on Oct 15, 1982in JAMA 47.66
Martin B. Keller113
Estimated H-index: 113
Gerald L. Klerman73
Estimated H-index: 73
+ 3 AuthorsJean Endicott94
Estimated H-index: 94
We report on the treatment received by 217 patients in the community with a diagnosis of major depressive disorder of at least one month's duration. Only a low proportion of subjects received intensive treatment with antidepressant medication or electroconvulsive therapy, as judged by research standards and current clinical teaching. Specific associations emerge between treatment and several clinical, sociodemographic, and diagnostic variables; however, taken together these variables account for...
222 Citations Source Cite
Published on Nov 1, 1970in Technometrics 1.57
James V. Bradley1
Estimated H-index: 1
(University of Michigan)
1,594 Citations Source Cite
Published on Jul 1, 1980in Archives of General Psychiatry
Hagop S. Akiskal95
Estimated H-index: 95
Ted L. Rosenthal15
Estimated H-index: 15
+ 3 AuthorsAlice Scott-Strauss4
Estimated H-index: 4
• Early-onset characterological depressions are distinguished from late-onset chronic depressions that complicate the longterm course of unipolar and nonaffective illnesses. In turn, characterological depressions are divisible into at least two subtypes: (1) "Subaffective dysthymias" have even sex distribution, are often complicated by superimposed depressive episodes, rapid eye movement latency is shortened, and they tend to respond to tricyclics or lithium carbonate. In brief, they share many ...
263 Citations Source Cite
Published on Jan 1, 1981
Rupert G. Miller1
Estimated H-index: 1
2,913 Citations
Published on Jan 1, 1979in American Journal of Psychiatry 13.40
Katz Mm1
Estimated H-index: 1
Klerman Gl1
Estimated H-index: 1
THE IMPETUS for the NIMH-Clinical Research Branch Collaborative Program on the Psychobiology of Depression stemmed from the growing concern with depression as a U.S. public health problem and the growing awareness that there had been some striking changes over the past 20 years in our conception of the nature and etiology of the affective disorders. New findings in the area of genetics and biochemistry inspired hypotheses implicating the chemistry of the endocrine and central nervous systems in ...
120 Citations Source Cite
Cited By200
Danny R. Dixon2
Estimated H-index: 2
(Florida State University),
Bruce A. Thyer34
Estimated H-index: 34
(University of Georgia)
Differences between male veterans diagnosed with major depression alone and male veterans diagnosed with both major depression and dysthymia (double depression) were investigated. Assessment instruments included the Structured Clinical Interview for DSM-III-R, the Beck Depression Inventory (BDI), and the Symptom Checklist-90-R (SCL-90-R). Consistent with prior literature, it was hypothesized that male veterans diagnosed with both major depression and dysthymia display more severe depressive symp...
2 Citations Source Cite
Published on Jul 1, 1986in American Journal of Psychiatry 13.40
Carlo Faravelli40
Estimated H-index: 40
Alessandra Ambonetti6
Estimated H-index: 6
+ 1 AuthorsAdolfo Pazzagli10
Estimated H-index: 10
METHOD Of 1 01 patients suffering from primary unipolar depression who were followed up for at least 1 year after recovery from the index episode, 51 relapsed into a new depressive episode within the year of recovery. Only those variables related to the period immediately after discharge distinguished nonrelapsers from relapsers; relapsers showed higher levels of residual symptoms, inferior social adaptation, a more pathological mean personality profile, and lower tricyclic plasma levels, despit...
126 Citations Source Cite
Published on Jun 1, 1992in American Journal of Psychiatry 13.40
Mario Maj59
Estimated H-index: 59
Veltro F1
Estimated H-index: 1
+ 2 AuthorsLorenza Magliano26
Estimated H-index: 26
Objective: This study assessed prospectively the pattern of recurrence of illness after recovery from an episode of major depression. Method: Seventy-two patients who had recovered from an episode of primary, nonbipolar, nonpsychotic major depression were evaluated bimonthly with the Comprehensive Psychopathological Rating Scale for a period ranging from 20 to 108 months (median=66 months]. New («prospective») episodes were ascertained with a structured diagnostic interview. The probabilities of...
178 Citations Source Cite
Published on Jan 1, 2001in The Journal of Clinical Psychiatry 4.25
Susan G. Kornstein39
Estimated H-index: 39
Robert K. Schneider1
Estimated H-index: 1
As many as 30% to 40% of patients with major depressive disorder are unresponsive to a trial of antidepressant medication. Many patients labeled with treatment-resistant depression actually have pseudoresistance, in that they have been inadequately treated or are misdiagnosed. Others may have unrecognized comorbid psychiatric or general medical conditions that contribute to treatment resistance. Variables such as gender, family history, age at onset, severity, and chronicity have also been evalu...
144 Citations
Published on Jun 1, 1989in American Journal of Psychiatry 13.40
Giles De1
Estimated H-index: 1
(University of Texas Southwestern Medical Center),
Robin B. Jarrett32
Estimated H-index: 32
+ 2 AuthorsRush Aj7
Estimated H-index: 7
(University of Texas Southwestern Medical Center)
In a longitudinal study of 30 successfully treated unipolar depressed patients, the authors evaluated number of depressive episodes, early onset of depression, and lifetime prevalence of affective disorders other than major depression as risk factors for recurrence. Early onset of depression (before age 20) and a history of affective disorders other than major depression were each significantly associated with recurrence. Number of episodes was not as powerful in predicting recurrence as either ...
55 Citations Source Cite
Published on Feb 1, 1995in British Journal of Psychiatry 5.87
J. A. Costa e Silva1
Estimated H-index: 1
Hugh Freeman9
Estimated H-index: 9
50 Citations Source Cite
Published on Jan 1, 1989in Acta Psychiatrica Scandinavica 4.98
R. Alnæs7
Estimated H-index: 7
(University of Oslo),
Svenn Torgersen45
Estimated H-index: 45
(University of Oslo)
The relationship between patients with acute major depression and chronic affective disorders was investigated in 298 nonpsychotic outpatients. The patients were categorized into 4 groups: major depression only, major depression with dysthymic or cyclothymic disorder, dysthymic or cyclothymic disorder without major depression and one group of other psychiatric disorders. The patients were interviewed about childhood losses, relationship to parents and siblings and family atmosphere, their person...
19 Citations Source Cite
Published on Nov 1, 2015in Journal of Affective Disorders 3.79
Antony Loebel28
Estimated H-index: 28
Cynthia Siu18
Estimated H-index: 18
+ 3 AuthorsTerence A. Ketter66
Estimated H-index: 66
(Stanford University)
Abstract Background In this post-hoc analysis, rates of remission and recovery were evaluated in patients with bipolar depression treated with lurasidone. Methods Outpatients meeting DSM-IV-TR criteria for bipolar I depression, were randomized to 6 weeks of once-daily, double-blind treatment with lurasidone 20–60 mg, lurasidone 80–120 mg or placebo, followed by a 6-month, open-label, flexible-dose, lurasidone continuation study. Recovery was defined as meeting criteria for combined symptomatic r...
5 Citations Source Cite
Published on Jan 1, 1988in American Journal of Psychiatry 13.40
Robert M. Post110
Estimated H-index: 110
(National Institutes of Health),
Peter Roy-Byrne70
Estimated H-index: 70
(National Institutes of Health),
Thomas W. Uhde52
Estimated H-index: 52
(National Institutes of Health)
152 Citations Source Cite
Published on Jun 1, 1991in American Journal of Psychiatry 13.40
R. Guscott1
Estimated H-index: 1
P. Grof1
Estimated H-index: 1
OBJECTIVE: The authors' goal is to address the complex issue of treatment-refractory depression from a clinical perspective. DATA COLLECTION: They review the literature on the major clinical and methodological issues involved in the treatment and study of treatment-refractory depression as well as primary and tertiary care surveys of patients whose depression has not responded to treatment. FINDINGS: There are methodological problems in defining treatment-refractory depression and in the tertiar...
88 Citations Source Cite