Overexpression ofmarA, soxS, oracrABproduces resistance to triclosan in laboratory and clinical strains ofEscherichia coli
Abstract
Triclosan (Irgasan) is a broad spectrum antimicrobial agent used in handsoaps, toothpastes, fabrics, and plastics. It inhibits lipid biosynthesis in Escherichia coli, probably by action upon enoyl reductase (FabI) (McMurry, L.M., Oethinger, M. and Levy, S.B. (1988) Nature 394, 531-532). We report here that overexpression of the multidrug efflux pump locus acrAB, or of marA or soxS, both encoding positive regulators of acrAB, decreased...
Paper Details
Title
Overexpression ofmarA, soxS, oracrABproduces resistance to triclosan in laboratory and clinical strains ofEscherichia coli
Published Date
Sep 1, 1998
Journal
Volume
166
Issue
2
Pages
305 - 309
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