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Soy isoflavone intake and bone mineral density in breast cancer survivors.

Published on Apr 1, 2015in Cancer Causes & Control2.3
· DOI :10.1007/s10552-015-0534-3
Michelle L. Baglia4
Estimated H-index: 4
(Vandy: Vanderbilt University),
Kai Gu28
Estimated H-index: 28
(CDC: Centers for Disease Control and Prevention)
+ 7 AuthorsXiao-Ou Shu100
Estimated H-index: 100
(Vandy: Vanderbilt University)
Abstract
Purpose Low bone mineral density (BMD) is common among breast cancer survivors due to acute estrogen deprivation. Soy food is a rich source of phytoestrogens, namely isoflavones, known to have both estrogenic and anti-estrogenic effects. The objective of the study was to assess the association between soy consumption and BMD in breast cancer survivors, which has not previously been evaluated.
  • References (39)
  • Citations (9)
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References39
Newest
#1Freddie Ian BrayH-Index: 88
#2Jian Song Ren (IARC: International Agency for Research on Cancer)H-Index: 1
Last. Jacques Ferlay (IARC: International Agency for Research on Cancer)H-Index: 66
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Recent estimates of global cancer incidence and survival were used to update previous figures of limited duration prevalence to the year 2008. The number of patients with cancer diagnosed between 2004 and 2008 who were still alive at the end of 2008 in the adult population is described by world region, country and the human development index. The 5-year global cancer prevalence is estimated to be 28.8 million in 2008. Close to half of the prevalence burden is in areas of very high human developm...
1,061 CitationsSource
#1Sarah NechutaH-Index: 19
#2Bette J. CaanH-Index: 79
Last. Xiao-Ou ShuH-Index: 100
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Background: Soy isoflavones have antiestrogenic and anticancer properties but also possess estrogen-like properties, which has raised concern about soy food consumption among breast cancer survivors. Objective: We prospectively evaluated the association between postdiagnosis soy food consumption and breast cancer outcomes among US and Chinese women by using data from the After Breast Cancer Pooling Project. Design: The analysis included 9514 breast cancer survivors with a diagnosis of invasive b...
81 CitationsSource
#2Lúcia Costa-Paiva (State University of Campinas)H-Index: 23
Last. Aarão Mendes Pinto-Neto (State University of Campinas)H-Index: 25
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Summary Background: The aim of this study was to investigate the prevalence of low bone mineral density (BMD) and associated factors in middle-aged breast cancer survivors (BCS). Patients and Methods: A cross-sectional study was conducted with 70 BCS of 45–65 years of age undergoing complete oncology treatment. Logistic regression models were used to identify factors associated with low BMD (osteopenia and osteoporosis taken together as a single group). Results: The mean age of participants was ...
11 CitationsSource
#1Tsogzolmaa Dorjgochoo (VUMC: Vanderbilt University Medical Center)H-Index: 13
#2Kai GuH-Index: 28
Last. Xiao-Ou Shu (VUMC: Vanderbilt University Medical Center)H-Index: 100
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It has been suggested that soy food and its components may relieve menopausal symptoms (MPS) including hot flashes, night sweats, and vaginal dryness in healthy women. However, little is known about the effect of soy food intake on MPS in women with breast cancer. We examined associations of occurrence of MPS with soy food intake in 4,842 Chinese women aged 20–75 years who had non-metastatic breast cancer and had not used hormone replacement therapy. MPS were assessed at 6 and 36 months after ca...
9 CitationsSource
The objective of this paper is to carry out a systemic review of the literature investigating issues related to bone health in survivors of breast cancer. Given the fact that only a fraction of women with breast cancer receive appropriate assessment of their bone health, it is hoped that this review will help raise awareness of bone health concerns in this patient population. Articles published in the English language addressing issues related to bone health in breast cancer were accessed using ...
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#1Jacques Ferlay (IARC: International Agency for Research on Cancer)H-Index: 66
#2Hai Rim Shin (IARC: International Agency for Research on Cancer)H-Index: 1
Last. Donald Maxwell Parkin (University of Oxford)H-Index: 51
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Estimates of the worldwide incidence and mortality from 27 cancers in 2008 have been prepared for 182 countries as part of the GLOBOCAN series published by the International Agency for Research on Cancer. In this article, we present the results for 20 world regions, summarizing the global patterns for the eight most common cancers. Overall, an estimated 12.7 million new cancer cases and 7.6 million cancer deaths occur in 2008, with 56% of new cancer cases and 63% of the cancer deaths occurring i...
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#2Krista A. Power (UTU: University of Turku)H-Index: 1
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Dietary phytoestrogens, such as the lignan metabolite enterolactone (ENL) and the isoflavone genistein (GEN), are suggested to modulate the risk of estrogen-dependent disease (e.g., breast cancer) through regulation of estrogen signaling. However, the effects of complex food items containing lignans or isoflavones on estrogen receptor (ER) transactivation have not been assessed so far. In this study, the modulation of ER-mediated signaling by dietary sources of lignans (cereals and flaxseed) and...
30 CitationsSource
#2Robert M. LevyH-Index: 13
Last. Bruce P. BurnettH-Index: 17
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In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen-like effects of natural isoflavones and possible promotion or propagation of estrogen-sensitive cancers. These concerns are primarily based on in vitro and rodent data which suggest that genistein aglycone ca...
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#1Roberta De AngelisH-Index: 26
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The study relates the present evaluation of exposure to estrogenic isoflavones of French consumers through two approaches: (1) identification of the isoflavone sources in the French food offering, (2) a consumption-survey on premenopausal women. For the foodstuff approach 150 food-items were analysed for genistein and daidzein. Additionally, 12,707 labels of processed-foods from French supermarket websites and a restaurant-supplier website were screened, and 1616 foodstuffs of interest were reta...
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Summary Background and aim There is limited evidence on the link between the overall nutrients intake from diet and bone mineral density (BMD). We assessed the association between nutrient patterns and BMD among an ageing Australian population. Methods Participants (n = 1135; males, 45.8%; median age, 62.0 years) with dietary and BMD data in the North West Adelaide Health Study (NWAHS) were included. Dietary intake was assessed using a food frequency questionnaire. BMD was measured using dual-en...
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