Structural effects on the antitumour activity of a series of di(4‐substituted phenyl)tin dichloride complexes with nitrogen‐donor ligands

Investigation of the antitumour activity of a series of diorganotin dichloride complexes (4‐ZC 6 H 4 ) 2 SnCl 2 ·L 2 , where Z = OMe, Me, F, Cl, and CF 3 and L 2 = 2,2′‐bipyridyl (bipy), 1,10‐phenanthroline (phen) and 2‐aminomethylpyridine (amp) is reported. A number of these complexex are shown to exhibit reproducible activity in vivo towards P388 lymphocytic leukaemia in mice. 1 H NMR data are reported for an extended series of (4‐ZC 6 H 4 ) 4...